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Ohio State sophomore running back Dan Herron will miss Saturday's game at Purdue and possibly more time after reaggravating his left ankle injury against Wisconsin.
Herron originally sustained the injury Sept. 26 against Illinois and sat out the following week at Indiana. He returned last Saturday but had only two carries for eight yards before leaving the game. Herron started Ohio State's first four contests this season.
"We probably got set back a week or two," Ohio State head coach Jim Tressel said Tuesday.
Junior Brandon Saine will make his third consecutive start at running back and be backed up by freshman Jordan Hall.
Tressel remains hopeful that freshman Jaamal Berry, who has been bothered by a hamstring injury, can get on the field soon. The coach also wants to get former fullback Jermil Martin more time at running back.
"When he's been healthy he's been very, very good, but right now it's Brandon and Jordan," Tressel said. "But Jaamal Berry has been back [at practice], got a lot of reps."
Tressel expects offensive tackles Andrew Miller and Jim Cordle both to return this week. Miller missed the last two games with the flu, while Cordle has been sidelined three games with an ankle injury.
Miller and Cordle opened the season as starters and were replaced by sophomores J.B. Shugarts and Mike Adams during their absences. Adams and Shugarts are listed as the starters on this week's depth chart.Adam Rittenberg covers Big Ten football for ESPN.com. He can be reached at firstname.lastname@example.org.