Chiefs coach Todd Haley declined to discuss Sheffield's status but one player said he was moving.
It's the second straight week the Chiefs have had a player removedon a cart. Last week it was cornerback Maurice Leggett, whose injuries are said not to be career-threatening.
"Our thoughts, prayers are with Cameron Sheffield," Haley said. "That's two of those situations in two weeks. Right now I don't have any information I feel comfortable in giving because again, there's a lot of people out there that are family and friends of Cameron's. I don't want to say anything that ends up being wrong."
Sheffield was hurt when his helmet made contact with Mike Bell's helmet as he took down the Eagles running back near the Chiefs' sideline.
Trainers and coaches tended to the rookie linebacker for several minutes before securing his body and lifting it onto a cart. He was conscious and medical personnel were talking to him.
Sheffield was drafted in the fifth round out of Troy and is competing for a job as a backup.
Information from The Associated Press contributed to this report.