Newton broke Heisman Trophy winner Pat Sullivan's 40-year-old mark with a 49-yard touchdown run in the third quarter. He came in leading the nation with 13 scores passing and 12 rushing for the No. 5 Tigers.
Newton had a 1-yard touchdown run in the first quarter. On his next score, he righted himself with his right hand after nearly getting tripped up.
Then, the Heisman Trophy candidate juked two defenders and dragged LSU cornerback Patrick Peterson into the end zone with 11:10 left in the third.
Also, kicker Wes Byrum has become the leading scorer in Tigers history.
Byrum broke John Vaughn's record with an extra point and then a 42-yard field goal in the second quarter of No. 5 Auburn's game against No. 6 LSU on Saturday.
Byrum came in three points shy of Vaughn's school record of 312 set from 2003-06. He set the single-season school mark for points by a kicker with 99 last season. With 69 coming into the game, he's on track to challenge that mark.
Information from The Associated Press contributed to this report.