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Belfort was scheduled to meet Wanderlei Silva in the card's main event, which will be held June 23 in Belo Horizonte, Brazil.
"I wake up this morning and Vitor Belfort breaks his hand, and he's in surgery," said White, who also learned Saturday that UFC ring-card girl Arianny Celeste was arrested by Las Vegas police and charged with domestic violence. "It never ends for me. Every day we get up and bad (stuff) happens.
"And guess what? I can guarantee you that when I wake up tomorrow something else is going to happen."
Despite Belfort's injury, White intends to keep Silva on the UFC 147 card. He hasn't yet decided who the former Pride middleweight champion (205 pounds) will face.
"I'm working on it," White said. "Wanderlei will fight."
The past two weeks have been difficult for White and UFC.
Light heavyweight champion Jon Jones was arrested May 21 on suspicion of drunken driving after crashing his car into a utility pole in Binghamton, N.Y.
The Nevada State Athletic Commission on May 21 handed welterweight contender Nick Diaz a one-year suspension due to his positive test result for marijuana metabolites following an interim title-bout loss Feb. 4 to Carlos Condit.
As for Celeste, whose real name is Arianny Lopez, White intends to offer his full support.
"Arianny is our baby," White said in a statement. "She has been with us for over five years. She is a good girl and an amazing ambassador for the UFC.
"I don't know all the details of what happened, but we have her back and support her 100 percent."