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Werdum weighed 242 pounds; Nogueira tipped the scale at 237.
A victory will extend Werdum's winning streak to three and allow him to avenge a unanimous decision loss to Nogueira in July 2006. Werdum, ranked fourth among heavyweights by ESPN.com, will enter the Octagon with a record of 16-5-1.
Nogueira, a former UFC interim heavyweight champion, will seek his second win in a row. He defeated Dave Herman by second-round armbar submission in October 2012 to improve to his pro mark to 34-7-1.
Light heavyweights Thiago Silva and Rafael Cavalcante get to settle their recent dispute. Silva checked in at 206 pounds; Cavalcante weighed 204.
Every fighter on the card qualified for the event. However, middleweight Ronny Markes was involved in a car accident earlier Friday and was pulled from the event. He was slated to face Derek Brunson.
According to UFC officials, Markes was not seriously injured.