Are the 49ers for real? If so, who would've predicted a Week 6 showdown between San Francisco and Detroit would be the showcase game for the NFC? And with Matthew Stafford, Calvin Johnson, and Frank Gore all on the same field, this is a must-watch game for fantasy owners as well.
But who will come out on top? That's where EA Sports comes in to help fill out the details before the games are even played. Using the advanced artificial intelligence of "Madden NFL 12," we've simulated all of the results, including winners, statistical leaders, and even the player of the game for every contest.
So click on the link before you fill out those fantasy lineups and see who "Madden" thinks will show up big this weekend.