USC wide receiver Marqise Lee will not play against Utah on Saturday because of a left knee injury, a source told ESPN.
Lee missed most of the second half of a loss to Notre Dame last Saturday after aggravating the injury.
The Trojans are hoping wide receivers Darreus Rogers and De'Von Flournoy can play through injuries against Utah.
Wide receiver Nelson Agholor (ribs) is questionable. The Trojans are preparing to play walk-on wide receivers Christian Tober, Cody Skene, George Katrib and Robby Kolanz, a former intern in the USC sports information office.
USC will be without its injured top three tight ends: Xavier Grimble (ankle), Randall Telfer (knee) and Jalen Cope-Fitzpatrick.
Walk-on tight ends Shane Sullivan and Chris Willson, a former pitcher at Wake Forest, are expected to play.
Running backs Tre Madden (hamstring) and Ty Isaac are questionable. Running back Justin Davis will miss the rest of the season following ankle surgery.
USC dressed only 48 scholarship players against Notre Dame.