The severity of the injury was not known immediately after the game, but Paul did undergo an examination with the team trainers.
"I don't want to speculate," Clippers coach Vinny Del Negro said in his postgame press conference. "His leg got tight. We'll see if it's a cramp, a strain, whatever it is, and we'll evaluate it.
"Chris is a fighter. He's competitive. If he can get out there, he will, and we'll be smart about it because we have a lot of games still left."
The injury was called a strain by the Clippers' staff. Asked how it happened, Paul said he didn't know and would find out when reviewing the film from the game.
"I'm so focused on everything else," he said. "I just know it was sometime in the fourth quarter."
It appeared as if it occurred with 4:01 left in the game, when Paul made a step-back jumper over the Lakers' Darius Morris and Andrew Bynum but came up lame upon hitting the ground. Randy Foye came in for him at the ensuing timeout, and Paul did not return to the game.
He said he told the coaching staff he was ready to go back in shortly afterward, only to have head trainer Jasen Powell tell him he could worsen the injury by returning.
"He said it was in my best interest not to go back," Paul said.
Paul, in his seventh season in the league, had a season-high 33 points for the Clippers against the Lakers, shooting 12-of-22 for the game. He also had six assists in 39 minutes of play.
Pedro Moura is a staff writer for ESPNLosAngeles.com.