Paul officially has been listed as day-to-day by the Clippers. The five-time All-Star injured his knee with 54 seconds left in the Clippers' 104-101 loss to the Magic on Saturday when he collided with Orlando guard J.J. Redick.
"It's just a long season and the smart thing to do right now," Clippers coach Vinny Del Negro told the team's official website. "We'll just let him get some therapy, get some rest and make sure he heals up properly. Every day it will be kind of a game-time decision, but tonight he'll be out."
Clippers guard Eric Bledsoe made his first start of the season in place of Paul and finished with 14 points, four assists and three rebounds in the 99-73 victory over the Grizzlies.
"I'll be right there on the bench just like [Chauncey Billups], just like when I missed a couple of games last year," Paul said. "There for vocal [support] and tell guys what I see. I think it will be huge for me and Chauncey to be there for [Bledsoe]."
Paul leads the NBA with 386 assists and is averaging 9.7 assists per game, the league's second-best mark. He also leads the league with 97 steals and is averaging 2.62 steals per game. In his four games before the Memphis game, he had 54 assists.
The Grizzlies were without forward Rudy Gay, who was excused to attend his grandmother's funeral in Baltimore.
Bledsoe shined as a starting point guard in the preseason while Paul recovered from offseason thumb surgery. Bledsoe had 25 points, eight rebounds and six assists, including a game-tying layup with 3.1 seconds left against the Denver Nuggets, and had 22 points, 9 assists and 11 steals against the Los Angeles Lakers.
"We've got to do a good job helping [Bledsoe] a little bit, too," Del Negro said. "Guys have got to make shots and talk, and we've got to put him in a position to be successful. He's got to control the tempo, control his turnovers and run the team. It's nothing he's not capable of doing."
Information from The Associated Press was used in this report.