Team officials and doctors say Jefferson will miss the rest of the season for the 17th-ranked Blue Devils. The announcement came hours before their rivalry game with No. 8 North Carolina, a 76-72 loss.
Jefferson was averaging 11.4 points and 10.3 rebounds in nine games before breaking his foot in December.
The school says it will seek a medical hardship waiver for Jefferson that would make him eligible for next season.