OAKLAND, Calif. (AP) -- Alex Rodriguez reached another milestone Saturday, yet he wasn't about to make a big deal out of it.

Rodriguez homered and the Seattle Mariners stopped their longest losing streak of the season at three, beating the Oakland Athletics 6-4.

	Rodriguez

Mike Cameron put the Mariners ahead for good with an RBI double in the sixth inning and singled home a run in the eighth. Oakland had won four in a row.

Rodriguez's two-run homer off Kevin Appier (3-3) in the fifth gave the Mariners a 4-2 lead. It was his 12th home run of the season and 160th of his career, tying him with Alvin Davis for fourth-most in Seattle history.

"I had a bunch of bad pitches," Appier said. "That one cost the most. He did a real good job of hitting."

The two RBI gave Rodriguez 501 for his career.

"I'm going to get a lot more RBI and I want more," Rodriguez said. "What I really want are wins. I'm not worried yet about records. A thousand RBIs will come soon."

Brett Tomko (2-2) went five innings to earn his first win since April 22. He allowed four runs on seven hits.

"In the fifth I was disappointed in myself," Tomko said. "The first four innings I liked myself."

Jose Mesa pitched the ninth inning for his first save of the season, and his first since last Sept. 16.

The A's had the bases loaded in the fourth, but scored just one run.

"For me that's the key," said A's third baseman Eric Chavez, who popped up to end the inning. "We let them off the hook there. We didn't do anything with it."

Appier, who hadn't pitched since April 24 because of a strained right forearm, lasted 5 2/3 innings. He allowed five runs, three of them earned, on five hits and four walks. He struck out five.

Matt Stairs and Ben Grieve each singled home a run in the fifth to tie it at 4.

Jeremy Giambi hit his fourth homer of the season in the second for the A's. Grieve made it 2-all with an RBI single in the fourth.

Game notes
Appier was activated from the 15-day DL before the game. ... Infielder Frank Menechino was sent down to Triple-A Sacramento of the Pacific Coast League to make room for Appier. ... A's infielder Olmedo Saenz missed the game with a mild sprain in his right ankle. He's listed day-to-day. ... Seattle pinch-hitters are 3-for-19 (.158) with no RBI. ... The Mariners have lost 179 times to the A's, their most losses against any opponent. ... Appier's 13 career wins against Seattle are his most against any club. ... Edgar Martinez went 0-for-3 to end an 11-game hitting streak.