| MLB First Round Draft Picks - 2000 | ||||
| PICK | PLAYER | POS | TEAM | SCHOOL/HOMETOWN |
| 1 | Adrian Gonzalez | 1B | Florida Marlins | Chula Vista, CA |
| 2 | Adam Johnson | RHP | Minnesota Twins | San Diego, CA |
| 3 | Luis Montanez | SS | Chicago Cubs | Miami, FL |
| 4 | Mike Stodolka | LHP | Kansas City Royals | Corona, CA |
| 5 | Justin Wayne | RHP | Montreal Expos | Honolulu, HI |
| 6 | Rocco Baldelli | OF | Tampa Bay Devil Rays | Warwick, RI |
| 7 | Matt Harrington | RHP | Colorado Rockies | Palmdale, CA |
| 8 | Matt Wheatland | RHP | Detroit Tigers | San Diego, CA |
| 9 | Mark Phillips | LHP | San Diego Padres | Hanover, PA |
| 10 | Joe Torres | LHP | Anaheim Angels | Kissimmee, FL |
| 11 | Dave Krynzel | OF | Milwaukee Brewers | Henderson, NV |
| 12 | Joe Borchard | OF | Chicago White Sox | Camarillo, CA |
| 13 | Shaun Boyd | 2B | St. Louis Cardinals | Oceanside, CA |
| 14 | Beau Hale | RHP | Baltimore Orioles | Mauriceville, TX |
| 15 | Chase Utley | 2B | Philadelphia Phillies | Long Beach, CA |
| 16 | Billy Traber | LHP | New York Mets | El Segundo, CA |
| 17 | Ben Diggins | RHP | Los Angeles Dodgers | Phoenix, AZ |
| 18 | Miguel Negron | OF | Toronto Blue Jays | Caguas, PR |
| 19 | Sean Burnett | LHP | Pittsburgh Pirates | Wellington, FL |
| 20 | Chris Bootcheck | RHP | Anaheim Angels | LaPorte, IN |
| 21 | John Bonser | RHP | San Francisco Giants | Pinellas Park, FL |
| 22 | Phil Dumatrait | LHP | Boston Red Sox | Bakersfield, CA |
| 23 | David Espinosa | SS | Cincinnati Reds | Miami, FL |
| 24 | Blake Williams | RHP | St. Louis Cardinals | San Marcos, TX |
| 25 | Scott Heard | C | Texas Rangers | San Diego, CA |
| 26 | Corey Smith | SS | Cleveland Indians | Piscataway, NJ |
| 27 | Robert Stiehl | C | Houston Astros | Torrance, CA |
| 28 | David Parrish | C | New York Yankees | Yorba Linda, CA |
| 29 | Adam Wainwright | RHP | Atlanta Braves | St. Simons Island, GA |
| 30 | Scott Thorman | 3B | Atlanta Braves | Cambridge, Ontario |