| MLB Single-Season (Post 1900) Batting Leaders - Home Runs | |||||||||||||||
| PLAYER | YR | G | AB | R | H | 2B | 3B | HR | RBI | BB | SO | SB | CS | BA | |
| 1 | Barry Bonds | 2001 | 153 | 476 | 129 | 156 | 32 | 2 | 73 | 137 | 177 | 93 | 13 | 3 | .328 |
| 2 | Mark McGwire | 1998 | 155 | 509 | 130 | 152 | 21 | 0 | 70 | 147 | 162 | 155 | 1 | 0 | .299 |
| 3 | Sammy Sosa | 1998 | 159 | 643 | 134 | 198 | 20 | 0 | 66 | 158 | 73 | 171 | 18 | 9 | .308 |
| 4 | Mark McGwire | 1999 | 153 | 521 | 118 | 145 | 21 | 1 | 65 | 147 | 133 | 141 | 0 | 0 | .278 |
| 5 | Sammy Sosa | 2001 | 160 | 577 | 146 | 189 | 34 | 5 | 64 | 160 | 116 | 153 | 0 | 2 | .328 |
| 6 | Sammy Sosa | 1999 | 162 | 625 | 114 | 180 | 24 | 2 | 63 | 141 | 78 | 171 | 7 | 8 | .288 |
| 7 | Roger Maris | 1961 | 161 | 590 | 132 | 159 | 16 | 4 | 61 | 142 | 94 | 67 | 0 | 0 | .269 |
| 8 | Babe Ruth | 1927 | 151 | 540 | 158 | 192 | 29 | 8 | 60 | 164 | 138 | 89 | 7 | 6 | .356 |
| 9 | Babe Ruth | 1921 | 152 | 540 | 177 | 204 | 44 | 16 | 59 | 171 | 144 | 81 | 17 | 13 | .378 |
| 10 | Mark McGwire | 1997 | 156 | 540 | 86 | 148 | 27 | 0 | 58 | 123 | 101 | 159 | 3 | 0 | .274 |
| PLAYER | YR | G | AB | R | H | 2B | 3B | HR | RBI | BB | SO | SB | CS | BA | |
| 11 | Ryan Howard | 2006 | 159 | 581 | 104 | 182 | 25 | 1 | 58 | 149 | 108 | 181 | 0 | 0 | .313 |
| 12 | Jimmie Foxx | 1932 | 154 | 585 | 151 | 213 | 33 | 9 | 58 | 169 | 116 | 96 | 3 | 7 | .364 |
| 13 | Hank Greenberg | 1938 | 155 | 556 | 144 | 175 | 23 | 4 | 58 | 146 | 119 | 92 | 7 | 5 | .315 |
| 14 | Luis Gonzalez | 2001 | 162 | 609 | 128 | 198 | 36 | 7 | 57 | 142 | 100 | 83 | 1 | 1 | .325 |
| 15 | Alex Rodriguez | 2002 | 162 | 624 | 125 | 187 | 27 | 2 | 57 | 142 | 87 | 122 | 9 | 4 | .300 |
| 16 | Ken Griffey Jr. | 1998 | 161 | 633 | 120 | 180 | 33 | 3 | 56 | 146 | 76 | 121 | 20 | 5 | .284 |
| 17 | Ken Griffey Jr. | 1997 | 157 | 608 | 125 | 185 | 34 | 3 | 56 | 147 | 76 | 121 | 15 | 4 | .304 |
| 18 | Hack Wilson | 1930 | 155 | 585 | 146 | 208 | 35 | 6 | 56 | 190 | 105 | 84 | 3 | 0 | .356 |
| 19 | Alex Rodriguez | 2007 | 158 | 583 | 143 | 183 | 31 | 0 | 54 | 156 | 95 | 120 | 24 | 4 | .314 |
| 20 | David Ortiz | 2006 | 151 | 558 | 115 | 160 | 29 | 2 | 54 | 137 | 119 | 117 | 1 | 0 | .287 |
| PLAYER | YR | G | AB | R | H | 2B | 3B | HR | RBI | BB | SO | SB | CS | BA | |
| 21 | Ralph Kiner | 1949 | 152 | 549 | 116 | 170 | 19 | 5 | 54 | 127 | 117 | 61 | 6 | 0 | .310 |
| 22 | Mickey Mantle | 1961 | 153 | 514 | 132 | 163 | 16 | 6 | 54 | 128 | 126 | 112 | 12 | 1 | .317 |
| 23 | Babe Ruth | 1920 | 142 | 458 | 158 | 172 | 36 | 9 | 54 | 137 | 148 | 80 | 14 | 14 | .376 |
| 24 | Babe Ruth | 1928 | 154 | 536 | 163 | 173 | 29 | 8 | 54 | 142 | 135 | 87 | 4 | 5 | .323 |
| 25 | George Foster | 1977 | 158 | 615 | 124 | 197 | 31 | 2 | 52 | 149 | 61 | 107 | 6 | 4 | .320 |
| 26 | Mark McGwire | 1996 | 130 | 423 | 104 | 132 | 21 | 0 | 52 | 113 | 116 | 112 | 0 | 0 | .312 |
| 27 | Jim Thome | 2002 | 147 | 480 | 101 | 146 | 19 | 2 | 52 | 118 | 122 | 139 | 1 | 2 | .304 |
| 28 | Alex Rodriguez | 2001 | 162 | 632 | 133 | 201 | 34 | 1 | 52 | 135 | 75 | 131 | 18 | 3 | .318 |
| 29 | Mickey Mantle | 1956 | 150 | 533 | 132 | 188 | 22 | 5 | 52 | 130 | 112 | 99 | 10 | 1 | .353 |
| 30 | Willie Mays | 1965 | 157 | 558 | 118 | 177 | 21 | 3 | 52 | 112 | 76 | 71 | 9 | 4 | .317 |
| PLAYER | YR | G | AB | R | H | 2B | 3B | HR | RBI | BB | SO | SB | CS | BA | |
| 31 | Cecil Fielder | 1990 | 159 | 573 | 104 | 159 | 25 | 1 | 51 | 132 | 90 | 182 | 0 | 1 | .277 |
| 32 | Andruw Jones | 2005 | 160 | 586 | 95 | 154 | 24 | 3 | 51 | 128 | 64 | 112 | 5 | 3 | .263 |
| 33 | Ralph Kiner | 1947 | 152 | 565 | 118 | 177 | 23 | 4 | 51 | 127 | 98 | 81 | 1 | 0 | .313 |
| 34 | Willie Mays | 1955 | 152 | 580 | 123 | 185 | 18 | 13 | 51 | 127 | 79 | 60 | 24 | 4 | .319 |
| 35 | Johnny Mize | 1947 | 154 | 586 | 137 | 177 | 26 | 2 | 51 | 138 | 74 | 42 | 2 | 0 | .302 |
| 36 | Brady Anderson | 1996 | 149 | 579 | 117 | 172 | 37 | 5 | 50 | 110 | 76 | 106 | 21 | 8 | .297 |
| 37 | Sammy Sosa | 2000 | 156 | 604 | 106 | 193 | 38 | 1 | 50 | 138 | 91 | 168 | 7 | 4 | .320 |
| 38 | Albert Belle | 1995 | 143 | 546 | 121 | 173 | 52 | 1 | 50 | 126 | 73 | 80 | 5 | 2 | .317 |
| 39 | Greg Vaughn | 1998 | 158 | 573 | 112 | 156 | 28 | 4 | 50 | 119 | 79 | 121 | 11 | 4 | .272 |
| 40 | Prince Fielder | 2007 | 158 | 573 | 109 | 165 | 35 | 2 | 50 | 119 | 90 | 121 | 2 | 2 | .288 |
| PLAYER | YR | G | AB | R | H | 2B | 3B | HR | RBI | BB | SO | SB | CS | BA | |
| 41 | Jimmie Foxx | 1938 | 149 | 565 | 139 | 197 | 33 | 9 | 50 | 175 | 119 | 76 | 5 | 4 | .349 |
| 42 | Andre Dawson | 1987 | 153 | 621 | 90 | 178 | 24 | 2 | 49 | 137 | 32 | 103 | 11 | 3 | .287 |
| 43 | Mark McGwire | 1987 | 151 | 557 | 97 | 161 | 28 | 4 | 49 | 118 | 71 | 131 | 1 | 1 | .289 |
| 44 | Barry Bonds | 2000 | 143 | 480 | 129 | 147 | 28 | 4 | 49 | 106 | 117 | 77 | 11 | 3 | .306 |
| 45 | Larry Walker | 1997 | 153 | 568 | 143 | 208 | 46 | 4 | 49 | 130 | 78 | 90 | 33 | 8 | .366 |
| 46 | Ken Griffey Jr. | 1996 | 140 | 545 | 125 | 165 | 26 | 2 | 49 | 140 | 78 | 104 | 16 | 1 | .303 |
| 47 | Sammy Sosa | 2002 | 150 | 556 | 122 | 160 | 19 | 2 | 49 | 108 | 103 | 144 | 2 | 0 | .288 |
| 48 | Albert Belle | 1998 | 163 | 609 | 113 | 200 | 48 | 2 | 49 | 152 | 81 | 84 | 6 | 4 | .328 |
| 49 | Jim Thome | 2001 | 156 | 526 | 101 | 153 | 26 | 1 | 49 | 124 | 111 | 185 | 0 | 1 | .291 |
| 50 | Shawn Green | 2001 | 161 | 619 | 121 | 184 | 31 | 4 | 49 | 125 | 72 | 107 | 20 | 4 | .297 |