| MLB Single-Season (Post 1900) Pitching Leaders - Strikeouts | |||||||||||||||
| PLAYER | YR | G | GS | CG | SH | IP | H | ER | BB | SO | W | L | SV | ERA | |
| 1 | Nolan Ryan | 1973 | 41 | 39 | 26 | 4 | 326.0 | 238 | 104 | 162 | 383 | 21 | 16 | 1 | 2.87 |
| 2 | Sandy Koufax | 1965 | 43 | 41 | 27 | 8 | 335.2 | 216 | 76 | 71 | 382 | 26 | 8 | 2 | 2.04 |
| 3 | Randy Johnson | 2001 | 35 | 34 | 3 | 2 | 249.2 | 181 | 69 | 71 | 372 | 21 | 6 | 0 | 2.49 |
| 4 | Nolan Ryan | 1974 | 42 | 41 | 26 | 3 | 333.0 | 221 | 107 | 202 | 367 | 22 | 16 | 0 | 2.89 |
| 5 | Randy Johnson | 1999 | 35 | 35 | 12 | 2 | 271.2 | 207 | 75 | 70 | 364 | 17 | 9 | 0 | 2.48 |
| 6 | Rube Waddell | 1904 | 46 | 46 | 39 | 8 | 383.0 | 307 | 69 | 91 | 349 | 25 | 19 | 0 | 1.62 |
| 7 | Bob Feller | 1946 | 48 | 42 | 36 | 10 | 371.1 | 277 | 90 | 153 | 348 | 26 | 15 | 4 | 2.18 |
| 8 | Randy Johnson | 2000 | 35 | 35 | 8 | 3 | 248.2 | 202 | 73 | 76 | 347 | 19 | 7 | 0 | 2.64 |
| 9 | Nolan Ryan | 1977 | 37 | 37 | 22 | 4 | 299.0 | 198 | 92 | 204 | 341 | 19 | 16 | 0 | 2.77 |
| 10 | Randy Johnson | 2002 | 35 | 35 | 8 | 4 | 260.0 | 197 | 67 | 71 | 334 | 24 | 5 | 0 | 2.32 |
| PLAYER | YR | G | GS | CG | SH | IP | H | ER | BB | SO | W | L | SV | ERA | |
| 11 | Nolan Ryan | 1972 | 39 | 39 | 20 | 9 | 284.0 | 166 | 72 | 157 | 329 | 19 | 16 | 0 | 2.28 |
| 12 | Randy Johnson | 1998 | 34 | 34 | 10 | 6 | 244.1 | 203 | 89 | 86 | 329 | 19 | 11 | 0 | 3.28 |
| 13 | Nolan Ryan | 1976 | 39 | 39 | 21 | 7 | 284.0 | 193 | 106 | 183 | 327 | 17 | 18 | 0 | 3.36 |
| 14 | Sam McDowell | 1965 | 42 | 35 | 14 | 3 | 273.0 | 178 | 66 | 132 | 325 | 17 | 11 | 4 | 2.18 |
| 15 | Curt Schilling | 1997 | 35 | 35 | 7 | 2 | 254.1 | 208 | 84 | 58 | 319 | 17 | 11 | 0 | 2.97 |
| 16 | Sandy Koufax | 1966 | 41 | 41 | 27 | 5 | 323.0 | 241 | 62 | 77 | 317 | 27 | 9 | 0 | 1.73 |
| 17 | Curt Schilling | 2002 | 36 | 35 | 5 | 1 | 259.1 | 218 | 93 | 33 | 316 | 23 | 7 | 0 | 3.23 |
| 18 | J.R. Richard | 1979 | 38 | 38 | 19 | 4 | 292.1 | 220 | 88 | 98 | 313 | 18 | 13 | 0 | 2.71 |
| 19 | Pedro Martinez | 1999 | 31 | 29 | 5 | 1 | 213.1 | 160 | 49 | 37 | 313 | 23 | 4 | 0 | 2.07 |
| 20 | Walter Johnson | 1910 | 45 | 42 | 38 | 8 | 370.0 | 262 | 56 | 76 | 313 | 25 | 17 | 1 | 1.36 |
| PLAYER | YR | G | GS | CG | SH | IP | H | ER | BB | SO | W | L | SV | ERA | |
| 21 | Steve Carlton | 1972 | 41 | 41 | 30 | 8 | 346.1 | 257 | 76 | 87 | 310 | 27 | 10 | 0 | 1.97 |
| 22 | Randy Johnson | 1993 | 35 | 34 | 10 | 3 | 255.1 | 185 | 92 | 99 | 308 | 19 | 8 | 1 | 3.24 |
| 23 | Mickey Lolich | 1971 | 45 | 45 | 29 | 4 | 376.0 | 336 | 122 | 92 | 308 | 25 | 14 | 0 | 2.92 |
| 24 | Mike Scott | 1986 | 37 | 37 | 7 | 5 | 275.1 | 182 | 68 | 72 | 306 | 18 | 10 | 0 | 2.22 |
| 25 | Sandy Koufax | 1963 | 40 | 40 | 20 | 11 | 311.0 | 214 | 65 | 58 | 306 | 25 | 5 | 0 | 1.88 |
| 26 | Pedro Martinez | 1997 | 31 | 31 | 13 | 4 | 241.1 | 158 | 51 | 67 | 305 | 17 | 8 | 0 | 1.90 |
| 27 | Sam McDowell | 1970 | 39 | 39 | 19 | 1 | 305.0 | 236 | 99 | 131 | 304 | 20 | 12 | 0 | 2.92 |
| 28 | J.R. Richard | 1978 | 36 | 36 | 16 | 3 | 275.1 | 192 | 95 | 141 | 303 | 18 | 11 | 0 | 3.11 |
| 29 | Walter Johnson | 1912 | 50 | 37 | 34 | 7 | 369.0 | 259 | 57 | 76 | 303 | 33 | 12 | 2 | 1.39 |
| 30 | Rube Waddell | 1903 | 39 | 38 | 34 | 4 | 324.0 | 274 | 88 | 85 | 302 | 21 | 16 | 0 | 2.44 |
| PLAYER | YR | G | GS | CG | SH | IP | H | ER | BB | SO | W | L | SV | ERA | |
| 31 | Vida Blue | 1971 | 39 | 39 | 24 | 8 | 312.0 | 209 | 63 | 88 | 301 | 24 | 8 | 0 | 1.82 |
| 32 | Nolan Ryan | 1989 | 32 | 32 | 6 | 2 | 239.1 | 162 | 85 | 98 | 301 | 16 | 10 | 0 | 3.20 |
| 33 | Curt Schilling | 1998 | 35 | 35 | 15 | 2 | 268.2 | 236 | 97 | 61 | 300 | 15 | 14 | 0 | 3.25 |
| 34 | Randy Johnson | 1995 | 30 | 30 | 6 | 3 | 214.1 | 159 | 59 | 65 | 294 | 18 | 2 | 0 | 2.48 |
| 35 | Curt Schilling | 2001 | 35 | 35 | 6 | 1 | 256.2 | 237 | 85 | 39 | 293 | 22 | 6 | 0 | 2.98 |
| 36 | Roger Clemens | 1997 | 34 | 34 | 9 | 3 | 264.0 | 204 | 60 | 68 | 292 | 21 | 7 | 0 | 2.05 |
| 37 | Roger Clemens | 1988 | 35 | 35 | 14 | 8 | 264.0 | 217 | 86 | 62 | 291 | 18 | 12 | 0 | 2.93 |
| 38 | Randy Johnson | 1997 | 30 | 29 | 5 | 2 | 213.0 | 147 | 54 | 77 | 291 | 20 | 4 | 0 | 2.28 |
| 39 | Randy Johnson | 2004 | 35 | 35 | 4 | 2 | 245.2 | 177 | 71 | 44 | 290 | 16 | 14 | 0 | 2.60 |
| 40 | Tom Seaver | 1971 | 36 | 35 | 21 | 4 | 286.1 | 210 | 56 | 61 | 289 | 20 | 10 | 0 | 1.76 |
| PLAYER | YR | G | GS | CG | SH | IP | H | ER | BB | SO | W | L | SV | ERA | |
| 41 | Rube Waddell | 1905 | 46 | 34 | 27 | 7 | 328.2 | 231 | 54 | 90 | 287 | 27 | 10 | 0 | 1.48 |
| 42 | Steve Carlton | 1980 | 38 | 38 | 13 | 3 | 304.0 | 243 | 79 | 90 | 286 | 24 | 9 | 0 | 2.34 |
| 43 | Steve Carlton | 1982 | 38 | 38 | 19 | 6 | 295.2 | 253 | 102 | 86 | 286 | 23 | 11 | 0 | 3.10 |
| 44 | Pedro Martinez | 2000 | 29 | 29 | 7 | 4 | 217.0 | 128 | 42 | 32 | 284 | 18 | 6 | 0 | 1.74 |
| 45 | Tom Seaver | 1970 | 37 | 36 | 19 | 2 | 290.2 | 230 | 91 | 83 | 283 | 18 | 12 | 0 | 2.82 |
| 46 | Sam McDowell | 1968 | 38 | 37 | 11 | 3 | 269.0 | 181 | 54 | 110 | 283 | 15 | 14 | 0 | 1.81 |
| 47 | Denny McLain | 1968 | 41 | 41 | 28 | 6 | 336.0 | 241 | 73 | 63 | 280 | 31 | 6 | 0 | 1.96 |
| 48 | Sam McDowell | 1969 | 39 | 38 | 18 | 4 | 285.0 | 222 | 93 | 102 | 279 | 18 | 14 | 1 | 2.94 |
| 49 | Dwight Gooden | 1984 | 31 | 31 | 7 | 3 | 218.0 | 161 | 63 | 73 | 276 | 17 | 9 | 0 | 2.60 |
| 50 | John Smoltz | 1996 | 35 | 35 | 6 | 2 | 253.2 | 199 | 83 | 55 | 276 | 24 | 8 | 0 | 2.94 |
