| MLB Career Pitching Leaders - Strikeouts | |||||||||||||||
| PLAYER | YRS | G | GS | CG | SH | IP | H | ER | BB | SO | W | L | SV | ERA | |
| 1 | Nolan Ryan | 27 | 807 | 773 | 222 | 61 | 5387.0 | 3923 | 1911 | 2795 | 5714 | 324 | 292 | 3 | 3.19 |
| 2 | Randy Johnson | 22 | 618 | 603 | 100 | 37 | 4135.1 | 3346 | 1513 | 1497 | 4875 | 303 | 166 | 2 | 3.29 |
| 3 | Roger Clemens | 24 | 709 | 707 | 118 | 46 | 4916.2 | 4185 | 1707 | 1580 | 4672 | 354 | 184 | 0 | 3.12 |
| 4 | Steve Carlton | 24 | 741 | 709 | 254 | 55 | 5217.1 | 4672 | 1864 | 1833 | 4136 | 329 | 244 | 2 | 3.22 |
| 5 | Bert Blyleven | 22 | 692 | 685 | 242 | 60 | 4970.0 | 4632 | 1830 | 1322 | 3701 | 287 | 250 | 0 | 3.31 |
| 6 | Tom Seaver | 20 | 656 | 647 | 231 | 61 | 4782.2 | 3971 | 1521 | 1390 | 3640 | 311 | 205 | 1 | 2.86 |
| 7 | Don Sutton | 23 | 774 | 756 | 178 | 58 | 5282.1 | 4692 | 1914 | 1343 | 3574 | 324 | 256 | 5 | 3.26 |
| 8 | Gaylord Perry | 22 | 777 | 690 | 303 | 53 | 5350.1 | 4938 | 1846 | 1379 | 3534 | 314 | 265 | 11 | 3.11 |
| 9 | Walter Johnson | 21 | 802 | 666 | 531 | 110 | 5914.2 | 4913 | 1424 | 1363 | 3509 | 417 | 279 | 34 | 2.17 |
| 10 | Greg Maddux | 23 | 744 | 740 | 109 | 35 | 5008.1 | 4726 | 1756 | 999 | 3371 | 355 | 227 | 0 | 3.16 |
| PLAYER | YRS | G | GS | CG | SH | IP | H | ER | BB | SO | W | L | SV | ERA | |
| 11 | Phil Niekro | 24 | 864 | 716 | 245 | 45 | 5404.1 | 5044 | 2012 | 1809 | 3342 | 318 | 274 | 29 | 3.35 |
| 12 | Fergie Jenkins | 19 | 664 | 594 | 267 | 49 | 4500.2 | 4142 | 1669 | 997 | 3192 | 284 | 226 | 7 | 3.34 |
| 13 | Pedro Martinez | 18 | 476 | 409 | 46 | 17 | 2827.1 | 2221 | 919 | 760 | 3154 | 219 | 100 | 3 | 2.93 |
| 14 | Bob Gibson | 17 | 528 | 482 | 255 | 56 | 3884.1 | 3279 | 1258 | 1336 | 3117 | 251 | 174 | 6 | 2.91 |
| 15 | Curt Schilling | 20 | 569 | 436 | 83 | 20 | 3261.0 | 2998 | 1253 | 711 | 3116 | 216 | 146 | 22 | 3.46 |
| 16 | John Smoltz | 21 | 723 | 481 | 53 | 16 | 3473.0 | 3074 | 1284 | 1010 | 3084 | 213 | 155 | 154 | 3.33 |
| 17 | Jim Bunning | 17 | 591 | 519 | 151 | 40 | 3760.1 | 3433 | 1366 | 1000 | 2855 | 224 | 184 | 16 | 3.27 |
| 18 | Mickey Lolich | 16 | 586 | 496 | 195 | 41 | 3638.1 | 3366 | 1390 | 1099 | 2832 | 217 | 191 | 11 | 3.44 |
| 19 | Mike Mussina | 18 | 537 | 536 | 57 | 23 | 3562.2 | 3460 | 1458 | 785 | 2813 | 270 | 153 | 0 | 3.68 |
| 20 | Cy Young | 22 | 906 | 815 | 749 | 76 | 7354.2 | 7092 | 2147 | 1217 | 2803 | 511 | 316 | 17 | 2.63 |
| PLAYER | YRS | G | GS | CG | SH | IP | H | ER | BB | SO | W | L | SV | ERA | |
| 21 | Frank Tanana | 21 | 638 | 616 | 143 | 34 | 4186.2 | 4063 | 1704 | 1255 | 2773 | 240 | 236 | 1 | 3.66 |
| 22 | David Cone | 17 | 450 | 419 | 56 | 22 | 2898.2 | 2504 | 1115 | 1137 | 2668 | 194 | 126 | 1 | 3.46 |
| 23 | Chuck Finley | 17 | 524 | 467 | 63 | 15 | 3197.1 | 3069 | 1366 | 1332 | 2610 | 200 | 173 | 0 | 3.85 |
| 24 | Tom Glavine | 22 | 682 | 682 | 56 | 25 | 4413.1 | 4298 | 1734 | 1500 | 2607 | 305 | 203 | 0 | 3.54 |
| 25 | Warren Spahn | 21 | 750 | 665 | 382 | 63 | 5243.2 | 4830 | 1798 | 1434 | 2583 | 363 | 245 | 29 | 3.09 |
| 26 | Bob Feller | 18 | 570 | 484 | 279 | 44 | 3827.0 | 3271 | 1384 | 1764 | 2581 | 266 | 162 | 21 | 3.25 |
| 27 | Jerry Koosman | 19 | 612 | 527 | 140 | 33 | 3839.1 | 3635 | 1433 | 1198 | 2556 | 222 | 209 | 17 | 3.36 |
| 28 | Tim Keefe | 14 | 599 | 593 | 554 | 39 | 5047.1 | 4437 | 1472 | 1224 | 2545 | 342 | 225 | 2 | 2.62 |
| 29 | Javier Vazquez | 14 | 450 | 443 | 28 | 8 | 2840.0 | 2784 | 1331 | 763 | 2536 | 165 | 160 | 0 | 4.22 |
| 30 | Christy Mathewson | 17 | 635 | 551 | 434 | 79 | 4780.2 | 4218 | 1133 | 844 | 2502 | 373 | 188 | 28 | 2.13 |
| PLAYER | YRS | G | GS | CG | SH | IP | H | ER | BB | SO | W | L | SV | ERA | |
| 31 | Don Drysdale | 14 | 518 | 465 | 167 | 49 | 3432.0 | 3084 | 1124 | 855 | 2486 | 209 | 166 | 6 | 2.95 |
| 32 | Jack Morris | 18 | 549 | 527 | 175 | 28 | 3824.2 | 3567 | 1657 | 1390 | 2478 | 254 | 186 | 0 | 3.90 |
| 33 | Mark Langston | 16 | 457 | 428 | 81 | 18 | 2962.2 | 2723 | 1306 | 1289 | 2464 | 179 | 158 | 0 | 3.97 |
| 34 | Jim Kaat | 25 | 898 | 625 | 180 | 31 | 4530.1 | 4620 | 1738 | 1083 | 2461 | 283 | 237 | 18 | 3.45 |
| 35 | Sam McDowell | 15 | 425 | 346 | 103 | 23 | 2492.1 | 1948 | 879 | 1312 | 2453 | 141 | 134 | 14 | 3.17 |
| 36 | Jamie Moyer | 25 | 696 | 638 | 33 | 10 | 4074.0 | 4231 | 1926 | 1155 | 2441 | 269 | 209 | 0 | 4.25 |
| 37 | Luis Tiant | 19 | 573 | 484 | 187 | 49 | 3486.1 | 3075 | 1280 | 1104 | 2416 | 229 | 172 | 15 | 3.30 |
| 38 | Dennis Eckersley | 24 | 1071 | 361 | 100 | 20 | 3285.2 | 3076 | 1278 | 738 | 2401 | 197 | 171 | 390 | 3.50 |
| 39 | Kevin Brown | 19 | 486 | 476 | 72 | 17 | 3256.1 | 3079 | 1185 | 901 | 2397 | 211 | 144 | 0 | 3.28 |
| 40 | Sandy Koufax | 12 | 397 | 314 | 137 | 40 | 2324.1 | 1754 | 713 | 817 | 2396 | 165 | 87 | 9 | 2.76 |
| PLAYER | YRS | G | GS | CG | SH | IP | H | ER | BB | SO | W | L | SV | ERA | |
| 41 | Charlie Hough | 25 | 858 | 440 | 107 | 13 | 3800.1 | 3283 | 1582 | 1665 | 2362 | 216 | 216 | 61 | 3.75 |
| 42 | Andy Pettitte | 17 | 509 | 499 | 25 | 4 | 3180.0 | 3299 | 1362 | 998 | 2359 | 249 | 145 | 0 | 3.85 |
| 43 | Robin Roberts | 19 | 676 | 609 | 305 | 45 | 4688.2 | 4582 | 1774 | 902 | 2357 | 286 | 245 | 25 | 3.41 |
| 44 | Early Wynn | 23 | 691 | 612 | 290 | 49 | 4564.0 | 4291 | 1796 | 1775 | 2334 | 300 | 244 | 15 | 3.54 |
| 45 | Rube Waddell | 13 | 407 | 340 | 261 | 50 | 2961.1 | 2460 | 711 | 803 | 2316 | 193 | 143 | 5 | 2.16 |
| 46 | Juan Marichal | 16 | 471 | 457 | 244 | 52 | 3507.1 | 3153 | 1126 | 709 | 2303 | 243 | 142 | 2 | 2.89 |
| 47 | Dwight Gooden | 16 | 430 | 410 | 68 | 24 | 2800.2 | 2564 | 1091 | 954 | 2293 | 194 | 112 | 3 | 3.51 |
| 48 | CC Sabathia | 12 | 393 | 393 | 35 | 12 | 2630.0 | 2433 | 1023 | 784 | 2270 | 195 | 105 | 0 | 3.50 |
| 49 | Lefty Grove | 17 | 616 | 457 | 298 | 35 | 3940.2 | 3849 | 1339 | 1187 | 2266 | 300 | 141 | 55 | 3.06 |
| 50 | Eddie Plank | 17 | 623 | 529 | 410 | 69 | 4495.2 | 3958 | 1174 | 1072 | 2246 | 326 | 194 | 23 | 2.35 |