The move was made before Friday night's game at Tampa Bay. Sizemore had been on the DL with a bruised right kneecap he injured making a hard, late slide into second base May 10.
Sizemore was the DH for the game with the Rays, something Cleveland manager Manny Acta said will be the case throughout the three-game series. Sizemore was dropped from his normal leadoff spot to sixth in the lineup.
"Grady hasn't played in two weeks, so he's got to get his timing down a little bit," Acta said. "We're going to put him back there for a few days up until he gets his timing down and we'll move him back."
Acta didn't rule out Sizemore playing the field once in the Indians' next series at Toronto, which also has artifical turf like Tropicana Field.
"After the first, like, 20 games of last year he's been pitched like Babe Ruth," Acta said. "He earned their respect pretty quick. Now he has to make the adjustment, he knows that. You have to learn the league, learn the sequences and just to also realize at times you're going to have take what they give him."
Sizemore reported no problems after running the bases this week, a final test before being cleared to play by Cleveland's medical and training staff.
In 18 games before he was hurt, he batted .282 with six home runs, 10 doubles and 11 RBIs.
Sizemore missed most of last season after having microfracture surgery on his left knee.
The Indians optioned outfielder Ezequiel Carrera to Triple-A Columbus after Wednesday's game against Boston to make room on the roster.
Injured designated hitter Travis Hafner, on the 15-day disabled list due to strained right oblique, is taking part in a rehab program but has not resumed baseball activities.