Cabrera left the Yankees' 7-4 win in Game 4 on Sunday night in the middle of the sixth inning with a slightly strained left hamstring. He took an awkward swing and appeared to hurt his leg while running out a grounder.
Brett Gardner, who took over for Cabrera on Sunday night, got his first career postseason start in center field in Game 5 on Monday night. He entered 2 for 5 with three runs and two caught stealings in the postseason.
Gardner was shaken up in the fifth inning after crashing into the fence in left-center while making a terrific catch of Jayson Werth's leadoff drive.
The speedy Gardner sprinted to the 387-foot sign and his back slammed into the wall, but he hung onto the ball. He rolled over on the warning track and took a minute to catch his breath.
Yankees manager Joe Girardi and assistant athletic trainer Steve Donohue came out to check on Gardner, but he stayed in the game.
One win from its 27th championship and first since 2000, New York went into the game with a 3-1 lead in the Series. The Yankees' lead, however, was trimmed to 3-2 after the Phillies won 8-6 in Game 5.
Pena, picked over pinch-runner Freddy Guzman and No. 3 catcher Francisco Cervelli, had not appeared in a game since the regular-season finale on Oct. 4. He had been working out at the team's complex in Tampa, Fla., to stay fresh in case the Yankees needed him.
"I was ready for anything and to be honest I really don't feel very nervous," Pena said. "If they need me to play, I'll be OK."
Once Major League Baseball approved the substitution, Pena said he found out for sure he would be added to the roster when he arrived at the ballpark Monday.
"You never know when you're going to get a call. Unfortunately, Melky got injured and I have the chance to be part of the roster," he said.
A smooth fielder, Pena hit .287 with a homer and 10 RBIs in 115 at-bats for the Yankees this season.
Cabrera, ineligible for the rest of the Series, batted .274 with 13 homers and 68 RBIs this season. He delivered some notable clutch hits, too.
The switch-hitter batted .271 in the postseason with four RBIs. He went 2 for 13 (.154) in the World Series.
Information from The Associated Press contributed to this report.