Byrd (1-2) scattered 11 hits over eight innings, allowing his only run on an eighth-inning RBI single by Raul Ibanez. The right-hander struck out three, walked none and worked out of a bases-loaded jam in the sixth by getting Randy Winn and Miguel Olivo on infield popups.
"I felt like it was my night after that," said Byrd, who stranded nine baserunners. "It's all about location and timing on the hits. I'm not a guy who gives up a ton more hits than innings pitched, but I didn't walk anybody and we made some really big defensive plays."
Byrd signed a one-year, $5 million contract with the Angels on Jan. 15, the same day they traded the underachieving Ramon Ortiz to Cincinnati. He improved his career record against the Mariners to
4-0 and lowered his ERA against them to 1.38.
"He threw a lot of strikes and got some big outs when he needed them," Seattle's Bret Boone said. "He relies on deception a lot. He's kind of El Duque-ish, hiding the ball real well from righties and throwing you a lot of different pitches. He's got five pitches -- a sinker, a cutter, a slider, a curveball and a changeup. ... You never know what's coming in any situation."
Suzuki, who set a major-league single-season record with 262 hits last season and won his second AL batting title, was 0-for-5. He faced Byrd four times and didn't get the ball out of the infield.
"He's a great hitter. But it's not like there's one way you can get him out or there's this game plan where if you throw the ball in one place, you can get him out," Byrd said. "He does a great job of putting the ball in play and not trying to do too much, and he never overswings."
Sele (1-1) allowed six runs and eight hits over four innings in his return to Angel Stadium. The right-hander pitched three seasons in Anaheim and won a World Series ring with them in 2002 but didn't pitch in the postseason that year because of a partially torn muscle in his rotator cuff that required surgery.
"He pitched his heart out for us last year, and I think he was an unsung hero of why we made our run in the second half to get to the playoffs," Angels manager Mike Scioscia said. "Aaron's a winner, and it seems like playoffs follow him. He'll do fine up there."
Last season, Sele became the first Angels pitcher to start a season 7-0. But the two-time All-Star experienced fatigue in his shoulder during a start on June 10 and was 5-4 with a 6.13 ERA in 16 starts after coming back from the disabled list. The Angels chose not to renew his contract, and he signed a minor-league deal with the Mariners.
"I obviously had great memories here, a lot of success and a lot of first-class teammates," Sele said. "The people in the front office are all class people who treated everybody well, and I enjoyed my time over here."
It also was a homecoming of sorts for third baseman Adrian Beltre, his first game in Southern California since leaving the Dodgers for free agency. Beltre, who led the majors last season with 48 home runs, was 1-for-4 with a double and received a mixed reaction from the crowd of 39,638 his first time up.
Garret Anderson opened the scoring with a sacrifice fly in the first inning and Guerrero added a two-run shot in the third that landed in the upper tier of the left field bullpen.
Erstad, who was aboard on a walk before Guerrero's fourth homer, hit his second of the season with two on in the third. He pulled a 2-2 pitch high off the screen attached to the right field pole, pushing the Angels' lead to 6-0.
"When I got hit 2-2, I tried to throw him a curve ball down," Sele said. "But I hung it out over the middle of the plate and he did a good job of keeping it fair."
By making the Mariners roster, Sele is getting a $700,000 salary this season and can earn an additional $400,000 in performance bonuses. ... Angels catcher Bengie Molina was placed on the 15-day disabled list with a strained right quadriceps. ... Rookie third baseman Dallas McPherson, who missed most of spring training with a herniated disc, made his season debut for the Angels. He was 0-for-4, booted Winn's routine grounder in the fourth for an error, and was thrown out trying to steal in the bottom of the inning. ... First baseman Richie Sexson was back in the Seattle lineup as the DH, going 1-for-4 after missing three games with the flu. ... Boone was 1-for-4 against Byrd and is 4-for-30 lifetime against him.