Inge hit a two-run homer off Jose Valverde with two outs in the ninth inning and the Tigers averted a sweep with a 4-3 win over the Astros on Sunday.
Tim Byrdak retired two batters in relief of Russ Ortiz in the eighth and Valverde (0-2) started the ninth, looking for his seventh save. Placido Polanco and Miguel Cabrera each flied out before Valverde walked Marcus Thames, an at-bat that Inge watched carefully.
When Valverde missed the strike zone with his first pitch to him, Inge correctly guessed that a straight fastball was coming next. He promptly drove the pitch over the left-field wall for his 18th home run to give Detroit its first lead.
"I noticed he walked Marcus with a split-finger (fastball), and threw me a first-pitch split-finger," Inge said. "I thought, I don't think he wants to fall behind both guys.' I just tried to stay on the fastball and be aggressive with it."
Valverde has blown four saves in 10 appearances this season.
"I had no idea what happened," Valverde said. "This guy's a good hitter. There's nothing I can do. I throw that pitch and he hit it."
Thanks to Inge, the Tigers feel a lot better heading to Oakland for a three-game series starting Monday. They play three games in Minnesota at the end of the week.
"To start off a road trip with a sweep against you, that's not how you want to do it," Inge said. "This is a big one, just to get us started in the right direction."
Curtis Granderson added a solo homer for the Tigers, who improved to 5-3 in the last eight games Jackson has started. Jackson came in with the AL's second-best ERA (2.40), behind Kansas City's Zack Greinke, and was as happy as anyone in the dugout when Inge homered.
"It's more for the team than for me," Jackson said. "A swing like that definitely gives us confidence going into the next series."
Jackson allowed only one hit through the first four innings, but the Tigers grounded into two early double plays. Detroit averaged only three runs in Jackson's previous seven starts.
Carlos Lee singled and one out later, Hunter Pence doubled down the left-field line. Keppinger and Lee scored, but a fan reached out of the stands and touched the ball. Lee's run was nullified and umpires ordered him to return to third base. Jackson struck out Ivan Rodriguez to end the inning and keep the score 2-0.
Inge beat out an infield single in the fifth and scored on Gerald Laird's double to left center. Laird was back in the lineup after leaving in the first inning of Saturday night's game with back spasms.
Granderson tied it in the sixth, driving a 1-1 pitch from Ortiz into the right-field seats for his 18th homer of the season. The Tigers have homered in 12 consecutive games, matching their longest streak since Sept. 4-17, 1999.
Geoff Blum, activated from the disabled list before the game, was hit by a pitch leading off the bottom of the seventh. Two outs later, Matsui doubled and Blum scored to give the Astros a 3-2 lead.
Ortiz retired Adam Everett leading off the eighth before he was replaced by Byrdak. The left-hander struck out the two batters he faced, not allowing a run for the 15th time in his last 18 appearances.
Aaron Boone, on the 60-day DL recovering from open-heart surgery, has been cleared to work out, the Houston Chronicle reported. ... Ortiz made his 300th career appearance. ... Detroit placed left-hander Nate Robertson on the 15-day disabled list with a mass in his left elbow. To take his place on the roster, the Tigers purchased the contract of left-hander Fu-Te Ni from Triple-A Toledo. He was 3-0 with a 2.60 ERA with 32 strikeouts in 24 appearances.
Information from The Associated Press was used in this report.