Arroyo allowed 10 runs and 11 hits in four innings. The right-hander's error in the third led to five unearned runs.
"Bronson wasn't sharp tonight, but he had to get his work in," Reds manager Dusty Baker said. "He feels good. He just wasn't sharp. He was missing."
Lou Marson hit a three-run homer in the fourth for Cleveland. The rookie, one of four players acquired in the July trade that sent Cliff Lee to Philadelphia, will share the catching duties with veteran Mike Redmond.
Triple-A right-hander Yohan Pino started for Cleveland and gave up three runs and three hits over 4 2/3 innings, including Brandon Phillips' solo homer in the second inning.
Mark Grudzielanek returned to the Indians' lineup after missing five days with a slightly strained right hamstring and had three hits and scored three times.
Grudzielanek, a 39-year-old who came to Cleveland's camp as a non-roster free agent, will be officially added to the team before the Indians open the season on Monday in Chicago. He's hitting .303 with five doubles and seven RBIs.
"Mark has showed all spring that he is still very athletic and a good player," manager Manny Acta said. "He brings experience, a good glove, and he's been getting timely hits."
Grudzielanek started at third base, a position he has not played in a big league game since 1995 as a rookie with the Montreal Expos. He's played primarily second base during a 14-year career, winning a gold glove at the position in 2006 with Kansas City.
RHP Mike Leake has earned a spot in the Reds' rotation. Cincinnati's No. 1 pick in 2009 from Arizona State will stay in the minor-league camp until the Reds need a fifth starter April 11. ... The Reds released RHP Kip Wells and sent eight to Triple-A Louisville: LHPs Aroldis Chapman, Travis Wood and Matt Maloney, RHPs Jared Burton and Justin Lehr, C Wilkin Castillo and INF-OFs Chris Burke and Drew Sutton. ... INF Aaron Miles and OF Wladimir Balentien were told they did not make the Reds 25-man roster. The team is trying to work out trades or negotiate with the players to stay in the organization. Miles is on a guaranteed $2.7 million contract. ... Cleveland purchased RHP Jamey Wright from Triple-A Columbus and reassigned RHP Saul Rivera, C-1B Chris Gimenez and INFs Brian Buscher, Niuman Romero and Luis Rodriguez to minor-league camp.