Until the seventh.
Adrian Gonzalez hit a go-ahead two-run double after Dustin Pedroia drove in a pair of runs during Boston's six-run inning, helping the Red Sox rally for a 7-5 win over the Houston Astros on Friday night.
Scutaro started the game with his third homer of the season, but Boston didn't get another hit until J.D. Drew began the seventh with a single.
"It won the game for us, so obviously it was big," Gonzalez said of the seventh. "We just had a great inning."
Houston starter Bud Norris struck out 10 in six-plus innings, but was charged with four runs and four hits in the opener of the third-ever series between these teams and first since 2008.
Red Sox knuckleballer Tim Wakefield yielded a season-high 11 hits with five runs in 5 1/3 innings in his first appearance against the Astros since July 1993 for the Pirates at the Astrodome.
Wakefield loved watching his team fight back from its four-run deficit.
"It was great," he said. "As bad as I pitched and we still came out on top, it's a huge boost for us."
Pence finished with two hits and two RBIs for the last-place Astros, who have dropped 12 of 16.
Reddick's RBI double in the seventh drove in Drew and chased Norris.
"We're just trying to find a way to score; it was kind of a weird game," Pedroia said. "(Norris) was very good early on so we were able to get him out of there and get some runs."
"We hadn't done a whole lot up to that point," Red Sox manager Terry Francona said. "We started to get something going. (McDonald) getting hit by that pitch, I know in the midst of all that it may not seem like a big deal, but all of the sudden they've got the bases loaded and they've got nowhere to put anybody and we strung together some good at-bats."
Norris walked one in the second, third, fifth and sixth, but largely stayed out of trouble until the seventh. All the strikeouts helped, including the side in the fourth inning.
"Bud pitched extremely well," Houston manager Brad Mills said. "We just couldn't stop that seventh inning. They got it started, and we just couldn't get it stopped."
The 26-year-old Norris is hoping Friday's experience will help him in the future.
"You take the good and the bad, and try to get better, and learn," he said. "That's where this team is at right now, a lot of young guys, learning day in and day out. That's what it's all about. I still need to learn to get better."
Carlos Lee had an RBI double for the Astros, and Angel Sanchez drove in a run with a bunt hit. Pence had a sacrifice fly in the first and a run-scoring ground-rule double in the second when a fan reached onto the field to try to grab the grounder and was escorted out of the stadium after the play.
David Ortiz, who is normally the designated hitter for Boston, struck out as a pinch hitter in the eighth inning.
Scutaro was batting leadoff with Jacoby Ellsbury out with an illness. Francona said Ellsbury was receiving fluids and he wasn't sure if he'd be ready to play Saturday. ... Houston 2B Jeff Keppinger was out for the second straight day after experiencing nausea before Thursday's game. ... Boston's Kevin Youkilis returned after sitting out Thursday's game in Philadelphia with a bone bruise in his left foot. ... Francona says LF Carl Crawford is unlikely to return to the lineup when he's due to come off the disabled list on Sunday. Crawford strained a hamstring in a June 17 game against Milwaukee. "He needs some more time," Francona said. Crawford, a Houston native, was disappointed that he probably won't get to play in his hometown this weekend. "We're trying to move as quickly as we can," Crawford said of his recovery. ... Francona says he may play Ortiz at first base on Saturday to face LHP J.A. Happ. Ortiz is hitting .341 against left-handers this season, and .290 against right-handers.