TORONTO -- The roof was closed at Rogers Centre, but there sure seemed to be a strong breeze blowing out of the dome.
"I don't care what level of baseball you're at, that first (win) is the toughest one to get," manager John Gibbons said. "Everybody wants to get off to a good start, and it's tough to come by."
"The wind was blowing out, apparently," Blue Jays left-hander Mark Buehrle, who surrendered two solo homers, said jokingly.
Arencibia had three hits and two RBIs. He had a second-deck drive to center in the second and a tiebreaking shot to left in the sixth, his seventh career multihomer game.
"I've always said that home runs win in this business and tonight's a perfect example," Gibbons said.
It was a welcome burst of offense by Toronto, held to three runs and nine total hits in their first two games after a winter overhaul remade the roster and boosted expectations for a playoff push.
"I think everyone has an idea of what this offense is capable of," Arencibia said. "Two games don't make your season and no one's worried. Everyone knows what we have in this clubhouse."
Buehrle echoed that, saying the win might get Jays fans to "step off the ledge a little bit."
Toronto's faithful might have to hold their breath a little longer, however, after Bautista left the game at the end of the eighth with a twisted ankle, suffered when he stepped on first base while beating out a double play relay.
"We don't think it's a big deal," said Gibbons, adding that Bautista will be re-evaluated before Friday's game against Boston.
Bautista called it "a tiny little tweak" and said he doesn't expect to miss any time.
"Hopefully tomorrow I'll wake up great and I'll be in the lineup and go beat the Red Sox," he said.
Consecutive doubles by Jason Kipnis and Nick Swisher gave the Indians a 1-0 lead in the first, but Toronto answered in the bottom half when Bautista drilled a two-run homer to left, his second in two days.
Arencibia's leadoff drive in the second put Toronto up 3-1, but the Indians tied it in the fourth on back-to-back homers by Santana and Reynolds, whose 11th inning blast decided Wednesday's 3-2 win for the Indians.
Encarnacion lined a three-run shot that just cleared the left field wall in the fifth, putting the Blue Jays up 6-3, but Cleveland answered again in the sixth. Santana hit an RBI double and Lonnie Chisenhall chased Buehrle with a two-run double to left, tying it at 6.
Buehrle allowed six runs and seven hits in 5 1/3 innings. He walked one and struck out four.
"Seven basehits, six extra-basehits, that's not me," Buehrle said.
Arencibia broke the tie with another second deck drive to begin the bottom of the sixth, bringing Cody Allen out of the Cleveland bullpen to replace Brett Myers. One out later, Rasmus hit a solo drive to right.
Emilio Bonifacio followed with a groundball double to center, then scored on a throwing error by Reynolds, giving Toronto a 9-6 lead. Back-to-back walks loaded the bases for Adam Lind, but he flied out to end the inning.
Myers (0-1) gave up seven runs and seven hits in five-plus innings in losing his sixth straight road decision. He walked two and struck out none.
"I couldn't get the ball down tonight, everything was up," Myers said. "Everything I threw was belt high or mast high and when I tried to get the ball down, I'd bounce it."
Reynolds hit an RBI single off Esmil Rogers in the seventh and Kipnis cut it to 9-8 with an RBI double off Darren Oliver in the eighth. Cleveland loaded the bases with two outs but second baseman Bonifacio ended the inning by ranging into shallow center to throw out Santana.
"Defensively, Bonifacio saved that game for us today," Arencibia said.
Toronto added an insurance run off Matt Albers in the eighth when Reyes scored from second on Bautista's fielder's choice grounder.
Cleveland placed LHP Scott Kazmir Indians on the 15-day disabled list with a strained right ribcage muscle, retroactive to April 2. Rookie RHP Trevor Bauer is expected to start in Kazmir's place Saturday at Tampa Bay. ... Toronto's Jose Reyes was shaken up after sliding headfirst into the shin of SS Asdrubal Cabrera on a steal of second in the fifth, but stayed in the game. ... The Blue Jays host former manager John Farrell and Red Sox on Friday night. Toronto RHP Josh Johnson will start against LHP Felix Doubront.