The Brewers' left-hander was up for the challenge Tuesday night, pitching seven solid innings to help Milwaukee beat Chicago 4-1 for its fifth consecutive victory.
"I'm certainly aware of who's pitching, but my approach to pitching doesn't change at all," Capuano said. "My goal is to hold them to the minimum number of runs possible.
"Zambrano is a good pitcher, but I try to do the same thing no matter who I'm pitching against," he said.
Capuano gave up one run on five hits while striking out six and walking none in his longest start of the season. It was his second consecutive victory, only the second time in his 32 major-league starts that he has won two straight.
Zambrano (2-1) extended his scoreless streak against Milwaukee to 12 1/3 innings before the Brewers scored three times in the sixth to send the Cubs to their third straight loss.
"He did throw the ball well, but Capuano pitched better," Chicago manager Dusty Baker said.
"He's running with it," Milwaukee manager Ned Yost said of Turnbow. "You give a kid like that an opportunity and for him to grab it and run, it's fun to see that."
Chicago scored its only run in the third on Henry Blanco's first home run of the year. The Cubs didn't get a runner past first after the third and managed only one hit in the final six innings.
In the decisive sixth inning, Brady Clark led off with a single and moved to third on Bill Hall's ground-rule double. Geoff Jenkins
followed with a sacrifice fly to left, scoring Clark to tie it at 1.
Carlos Lee then hit a hard liner down the left field line that got past third baseman Aramis Ramirez for his second double of the game, scoring Hall. Lyle Overbay was intentionally walked and Damian Miller doubled, scoring Lee to make it 3-1.
"We've gotten on a little bit of a roll, and we've done it with pitching and with great defense," Yost said. "Now we're starting to swing the bats and get some big hits when we've needed it."
In the eighth, Hall tripled, his third hit of the game, and scored on Overbay's double to finish the scoring.
Overbay's double extended his hitting streak to 10 games.
Zambrano, who threw 7 1/3 scoreless innings in a 4-0 victory over Milwaukee on April 9, pitched seven innings. He gave up three runs on seven hits and four walks (two intentional) while striking out a season-high 10.
Cubs right-hander Kerry Wood was placed on the 15-day disabled list because of a strained muscle in his right shoulder. Cubs trainer Mark O'Neal said Wood should be ready to pitch again after three weeks of rest to heal his strained shoulder. To take Wood's place on the roster, the Cubs recalled right-hander Todd Wellemeyer from Triple-A Iowa. ... Cubs center fielder Corey Patterson was ejected in the sixth inning by umpire Bob Davidson for throwing his helmet after arguing a close play at first. He was called out, but replays appeared to show he was safe. ... Chicago first baseman Derrek Lee singled in the sixth, extending his hitting streak to a career-high 14 games.