Brazelton gave up eight runs in four-plus innings Thursday and fell to 0-16 lifetime on the road when the Marlins defeated the San Diego Padres 9-2.
Mike Jacobs hit a three-run homer, his third, and Dan Uggla added a two-run homer, the first of his career. The Marlins, who came into the game with baseball's worst record, broke a five-game losing streak and improved to 2-6.
Along with the homers, Brazelton (0-2) gave up two doubles, two infield singles and four walks, hiking his career road ERA to 8.59 in 25 games. His winless streak on the road is the longest since Kent Peterson of Cincinnati lost his first 18 away decisions in 1947-49.
Brazelton acknowledged that he took the mound aware of the streak.
"I wanted to go out there and go right at them and attack it, because I don't want to be asked these questions anymore," he said. "But it just didn't happen that way. The first two games I've been humbled, but the season is not even two weeks old."
The lone bright spot for Brazelton: He drove in a run in the second inning with a double, his first major-league hit. On the mound, the right-hander has allowed four homers in 6 1/3 innings this season and has an ERA of 24.16.
"All I need is one good start to turn things around," he said. "I'm 0-2. Really, what does that mean? That means nothing. From my point of view, if I was 2-0, I wouldn't be winning the Cy Young, so at 0-2, why should I be totally upset and cash in the season?"
He might not be in the rotation much longer, however.
"Those are things we discuss on a daily basis," manager Bruce Bochy said. "I'd be lying if I said there was not some concern."
While homers hurt Brazelton, Hanley Ramirez did, too. The rookie shortstop, who has at least one hit in all eight games this season, scored three times and went 2-for-3 with two walks, hiking his average to .424.
"I'm feeling so comfortable right now," Ramirez said. "I'm just trying to keep it going."
Jacobs also scored three times, while another Florida rookie, Josh Willingham, had a pair of RBI doubles.
"The game always looks better when you hit," manager Joe Girardi said. "Guys swung at pitches in the zone that they liked."
Jason Vargas (1-1) walked five but limited the Padres to two hits and two runs in six innings. Three relievers completed a four-hitter.
Ramirez walked to reach base leading off the first for the sixth time in the seven games he has batted first. Uggla followed with an infield single, and Jacobs hit a one-out homer.
Ramirez started another rally in the third with a double. He advanced on a sacrifice and scored on Miguel Cabrera's groundout. Jacobs then walked with two out and scored on Willingham's double off the scoreboard.
Ramirez beat out a grounder to short for a hit leading off the fifth, and Uggla followed with a homer to make it 7-2. Brazelton left after walking Jacobs, and Willingham followed with an RBI double.
"I've always thought that hitting is contagious," Uggla said. "You see a couple of guys ahead of you get a hit and you think, 'This guy is pretty hittable.'"
Uggla was 13 years old the first time he batted against Brazelton -- in Babe Ruth League in Tennessee. They also faced each other in high school, college and the minor leagues.
"He's owned me," Uggla said. "The only hits I got off him were a home run in college and the home run today.
"He's had an up-and-down career, but he has big-league stuff. I think he's going to be around a long time," Uggla said.
Brazelton came within four outs of a no-hitter against the Marlins with Tampa Bay in 2004. ... The timetable for the return of Padres outfielder Mike Cameron (side muscle) has been moved up. He'll hit off a tee Friday and might be ready to play in a week, Bochy said. ... The Marlins optioned right-hander Chris Resop to Triple-A Albuquerque and recalled from Albuquerque left-hander Scott Olsen, who is scheduled to start Saturday against Washington. ... Marlins outfielder Jeremy Hermida
(right hip flexor) sat out his second game in a row, and his status remains day-to-day.