SAN DIEGO (AP) -- After enduring an awful few days, the San Diego Padres finally found something to feel good about.
Khalil Greene hit two solo home runs, and Adrian Gonzalez and Kevin Kouzmanoff each hit two-run shots to back starter Randy Wolf in the San Diego Padres' 8-2 win over the Cincinnati Reds on Thursday night.
The win comes on the heels of Wednesday night's 11-3 defeat to St. Louis when the last-place Padres lost starting pitcher Chris Young and catcher Josh Bard to injuries. Both players were placed on the disabled list before the game and joined NL Cy Young winner Jake Peavy, who went on the DL Tuesday with a strained and swollen right elbow.
San Diego, which has the worst record in the majors at 18-31, won for just the sixth time in 18 games.
"It's nice to be able to come back after a symbolically low point," Greene said. "We did a lot of things well."
Wolf was sharp after allowing Ken Griffey Jr. to hit his 598th home run in the first inning. The two-run shot was Griffey's first in 90 at-bats, the second longest homerless drought of his career. Griffey is attempting to become the sixth player in baseball history to reach 600 homers.
"Everything came together after the home run to Griffey," Padres manager Bud Black said. "I think you saw the command of the breaking ball. After the first inning, he seemed to lock in."
After Griffey's home run, Wolf (3-4) did not allow a baserunner past first. Wolf gave up two runs on four hits in seven innings. The left-hander struck out nine and walked one.
"I was able to make pitches when I need to," said Wolf, who also had an RBI single. "The first inning wasn't bad except getting behind Griffey and giving up that home run. It's tough to make that mistake early and put us in a hole, but luckily we were able to score some runs."
Griffey moved closer to the home run milestone when he hit a 3-1 fastball off Wolf an estimated 411 feet into the right-field seats with one out after Ryan Freel's leadoff single. Wolf is the 382nd pitcher to allow a home run to Griffey.
Griffey last homered on April 23 in Cincinnati off Houston's Chris Sampson.
"He's swinging the bat pretty good," Reds manager Dusty Baker said. "He's getting close to getting his stride together. Now we have to get some other guys to get their strokes together."
Cincinnati lost its fourth straight game.
Gonzalez's home run, his 13th, hit the right-field foul pole and put San Diego ahead 3-2 in the fifth inning against Aaron Harang (2-6). Greene hit the first of his two homers leading off the sixth against Harang.
Kouzmanoff greeted reliever Mike Lincoln with a two-run homer in the seventh and Greene immediately followed with his second to put San Diego up 8-2.
The eight runs were the most the Padres have scored since April 26, a span of 24 games. San Diego scored more than four runs in a game for just the third time in 18 games.
The four home runs were also a season high for the Padres, who last hit four homers at spacious Petco Park in August. San Diego had not hit more than two home runs in a game this season.
"The offense picked us up," Black said.
Harang allowed five runs on 10 hits in 5 1/3 innings. He struck out seven and walked two.
"I was rushing on everything," Harang said. "I wasn't executing my pitches and I was leaving them up."
Griffey also became the fourth player to hit at least 300 home runs with one team and 200 with a second. Griffey had 398 homers for the Seattle Mariners, with whom he played from 1989 to 1999, and has hit 200 home runs with the Reds. Mark McGwire, Rafael Palmeiro and Jimmie Foxx are the others to accomplish that feat.
Reds third baseman Edwin Encarnacion and Baker were ejected by home plate umpire Eric Cooper in the middle of the seventh inning. Encarnacion had been called out on strikes in the top of the seventh and had words with Cooper. When Encarnacion went out to his position in the middle of the inning, he said something to Cooper, who ejected him. Baker then came out and he was also ejected by Cooper. ... San Diego's Scott Hairston played against his older brother, Jerry Hairston Jr. for just the fourth time in their careers. Jerry came into the game after Encarnacion was ejected.