Swept in a three-game series at last-place Seattle to open their cross-continental journey, the A's recovered by taking two of three in Tampa Bay and two of three from the Blue Jays.
"We came into two places that are tough to play against two good teams that swing the bat," Oakland manager Bob Melvin said. "To take two out of three in both these places with what we had been doing on the road is a nice pick-me-up and a nice confidence rebuild after a tough series in Seattle."
The Athletics are 22-40 on the road this season and have won just 11 of their past 42 away from home.
"We had a tough series in Seattle but I think everybody took a good look at themselves," Matsui said through a translator. "Since we came to the East Coast, these were some tough opponents, but we made sure that we did the preparation that we needed to do and then executed on the field."
The A's failed to hit a home run for the first time in nine games but still finished with its most runs since scoring 13 against the Rays on July 27. Oakland's season high is 14 runs, set May 17 against the Los Angeles Angels.
Matsui had a 15-game hitting streak snapped Tuesday and was hitless in 10 at bats before hitting an RBI single in the third. He grounded out in the fourth but singled again in the sixth, seventh and ninth to finish 4-for-6. Matsui, who was hitting .209 at the All Star break, has raised his average to .268.
"The run that he's on is remarkable," Melvin said. "I don't know that I've been around a run like that, a consistent run. He never ceases to amaze you."
It was something of an adventurous day on the bases for Matsui, who was hit on the lower left leg by a pitch Wednesday and played despite minor swelling. Trotting home from second on Jackson's triple in the third, he was nearly caught by Josh Willingham, who crossed the plate just a few feet behind.
"I didn't know if Hideki was going to pass the baton to him," Melvin said.
Willingham, who said he was gaining on Matsui despite "jogging," made sure his teammate knew he was closing fast.
"He was right behind me yelling at me, 'Run, Matsui, run!'" Matsui said.
The Japanese slugger was nearly thrown out at second after lining an RBI single to right in the sixth, but shortstop Yunel Escobar didn't see him coming and fired the relay to the plate, allowing Matsui to take second.
"I was trying to trick them," he joked. "Apparently I was just making a fool out of myself. I actually even laughed at myself afterward."
Oakland right-hander Guillermo Moscoso (5-6) allowed two runs, one earned, in six innings to earn the win. He walked two and struck out six.
"I felt pretty good, I was making my pitches," Moscoso said. "I was working the slider today. That was the key, to get ahead in the count with the first two pitches and I was able to do whatever I wanted."
J.P. Arencibia hit his 19th home run for Toronto, a solo drive to center in the seventh, but it wasn't enough for the Blue Jays.
The A's chased Toronto starter Brad Mills with a six-run third. Cliff Pennington hit a two-run double, Matsui followed with an RBI single and, after Willingham was hit by a pitch, Jackson hit a two-run triple and scored on a wild pitch.
Mills (1-2) allowed six runs and five hits in three innings, his shortest career start. The left-hander walked two and struck out five.
"It's not the first time I've had a bad inning and it won't be the last," Mills said. "It's not the end of the world but I feel bad that I wasn't able to help the team get off to a good start."
Moscoso was perfect through the first three innings before walking Escobar to begin the fourth. One out later, Jose Bautista walked to put runners at first and second for Adam Lind, who grounded to shortstop. Trying for the double play, Pennington's relay to second base sailed into right field for an error, allowing Escobar to score and sending Bautista to third. Bautista came home one batter later on Edwin Encarnacion's infield single.
The Athletics padded their lead with a four-run sixth against reliever Luis Perez. Sizemore reached on a throwing error by third baseman Brett Lawrie, Pennington walked and Matsui hit an RBI single. Willingham walked to load the bases and Jackson hit a sacrifice fly.
Oakland second baseman Adam Rosales went 0-for-4 with a walk, extending his career-long hitless streak to 0-for-24. ... The A's have won four of their past five series. ... Athletics outfielder Coco Crisp (right calf) missed his fourth straight game and is expected to sit out the upcoming three-game series against the Texas Rangers. ... A's right-hander Michael Wuertz (right thumb) will not resume throwing until Aug. 15 and is unlikely to return before the end of the month. Wuertz was placed on the 15-day DL on July 30. ... Encarnacion has started taking fly balls in left field, manager John Farrell said, and could see some time in the outfield before the end of the season.