| Thursday, April 8, 2010 | |||||
| RESULT | WIN | LOSS | SAVE | ATT. | |
| at Cincinnati 2, St. Louis 1 | Cordero (1-0) | Motte (0-1) | 13,445 | ||
| LA Dodgers 10, at Pittsburgh 2 | Billingsley (1-0) | Maholm (0-1) | 9,352 | ||
| Toronto 3, at Texas 1 | Janssen (1-0) | Francisco (1-1) | Frasor (2) | 14,707 | |
| Detroit 7, at Kansas City 3 | Bonine (1-0) | Mendoza (0-1) | 10,909 | ||
| at Oakland 6, Seattle 2 | Anderson (1-0) | Fister (0-1) | 12,464 | ||
| at Washington 6, Philadelphia 5 | Clippard (1-0) | Figueroa (0-1) | Capps (1) | 20,217 | |
| Chicago Cubs 2, at Atlanta 0 | Wells (1-0) | Hanson (0-1) | Marmol (1) | 27,443 | |
| Florida 3, at NY Mets 1 | Robertson (1-0) | Niese (0-1) | Oviedo (1) | 25,982 | |
| Baltimore 5, at Tampa Bay 4 | Matusz (1-0) | Ekstrom (0-1) | Gonzalez (1) | 36,973 | |
| Cleveland 5, at Chicago White Sox 3 | Lewis (1-0) | Putz (0-1) | Perez (2) | 18,637 | |
| Minnesota 10, at LA Angels 1 | Slowey (1-0) | Pineiro (0-1) | 39,709 | ||
| Monday, April 12, 2010 | |||||
| RESULT | WIN | LOSS | SAVE | ATT. | |
| Kansas City 10, at Detroit 5 | Hochevar (1-0) | Scherzer (0-1) | 17,058 | ||
| at Chicago Cubs 9, Milwaukee 5 | Dempster (1-0) | Davis (0-1) | 41,306 | ||
| Texas 4, at Cleveland 2 | Francisco (2-2) | Wright (0-1) | Feliz (1) | 42,061 | |
| at Philadelphia 7, Washington 4 | Hamels (2-0) | Marquis (0-2) | Madson (2) | 44,791 | |
| at Minnesota 5, Boston 2 | Pavano (2-0) | Lester (0-1) | Rauch (5) | 38,145 | |
| at St. Louis 5, Houston 0 | Wainwright (2-0) | Rodriguez (0-2) | 46,918 | ||
| at San Diego 17, Atlanta 2 | Correia (1-1) | Jurrjens (0-1) | 42,843 | ||
| Oakland 4, at Seattle 0 | Duchscherer (1-0) | Rowland-Smith (0-1) | 45,876 | ||
| Tampa Bay 5, at Baltimore 1 | Garza (2-0) | Guthrie (0-2) | 9,129 | ||
| Cincinnati 6, at Florida 5 | Masset (2-0) | Badenhop (0-1) | Cordero (3) | 10,119 | |
| Chicago White Sox 8, at Toronto 7 | Thornton (1-0) | Accardo (0-1) | Jenks (2) | 46,321 | |
| at San Francisco 9, Pittsburgh 3 | Zito (2-0) | Burres (0-1) | 26,011 | ||
| Tuesday, April 13, 2010 | |||||
| RESULT | WIN | LOSS | SAVE | ATT. | |
| at Detroit 6, Kansas City 5 | Zumaya (2-0) | Hughes (0-1) | Valverde (2) | 18,414 | |
| at NY Yankees 7, LA Angels 5 | Pettitte (1-0) | Santana (0-2) | Rivera (3) | 49,283 | |
| at LA Dodgers 9, Arizona 5 | Kershaw (1-0) | Kennedy (0-1) | 56,182 | ||
| Tampa Bay 8, at Baltimore 6 | Cormier (1-0) | Albers (0-1) | Soriano (2) | 13,731 | |
| at Toronto 4, Chicago White Sox 2 | Romero (1-0) | Floyd (0-1) | Gregg (3) | 12,167 | |
| Cincinnati 10, at Florida 8 | Owings (2-0) | Meyer (0-1) | Cordero (4) | 10,681 | |
| at Colorado 11, NY Mets 3 | Smith (1-1) | Maine (0-1) | 25,110 | ||
| at Seattle 3, Oakland 0 | Fister (1-1) | Ziegler (0-2) | Aardsma (3) | 18,043 | |
| Pittsburgh 6, at San Francisco 5 | Meek (1-0) | Affeldt (2-1) | Dotel (2) | 28,030 | |