| Sunday, April 2, 2006 | |||||
| RESULT | WIN | LOSS | SAVE | ATT. | |
| at Philadelphia 5, Boston 0 | |||||
| at LA Angels 4, LA Dodgers 2 | |||||
| Oakland 5, at San Francisco 3 | |||||
| at Chicago Sox 10, Cleveland 4 (Reg. Season) | McCarthy (1-0) | Cabrera (0-1) | 38,802 | ||
| Monday, April 3, 2006 | |||||
| RESULT | WIN | LOSS | SAVE | ATT. | |
| at NY Mets 3, Washington 2 | Glavine (1-0) | Hernandez (0-1) | Wagner (1) | 54,371 | |
| at Milwaukee 5, Pittsburgh 2 | Lehr (1-0) | Torres (0-1) | Turnbow (1) | 45,023 | |
| Boston 7, at Texas 3 | Schilling (1-0) | Millwood (0-1) | 51,573 | ||
| Chicago Cubs 16, at Cincinnati 7 | Ohman (1-0) | Harang (0-1) | 42,591 | ||
| at Baltimore 9, Tampa Bay 6 | Lopez (1-0) | Kazmir (0-1) | Ray (1) | 46,986 | |
| St. Louis 13, at Philadelphia 5 | Carpenter (1-0) | Lieber (0-1) | 44,614 | ||
| at Colorado 3, Arizona 2 | DeJean (1-0) | Grimsley (0-1) | 47,278 | ||
| Detroit 3, at Kansas City 1 | Rogers (1-0) | Elarton (0-1) | Rodney (1) | 41,139 | |
| Atlanta 11, at LA Dodgers 10 | Villarreal (1-0) | Lowe (0-1) | Reitsma (1) | 56,000 | |
| LA Angels 5, at Seattle 4 | Shields (1-0) | Sherrill (0-1) | Rodriguez (1) | 45,509 | |
| at Houston 1, Florida 0 | Oswalt (1-0) | Johnson (0-1) | Lidge (1) | 43,666 | |
| at San Diego 6, San Francisco 1 | Peavy (1-0) | Schmidt (0-1) | 43,767 | ||
| NY Yankees 15, at Oakland 2 | Johnson (1-0) | Zito (0-1) | 35,077 | ||
| Tuesday, April 4, 2006 | |||||
| RESULT | WIN | LOSS | SAVE | ATT. | |
| Cleveland 8, at Chicago Sox 2 | Westbrook (1-0) | Garcia (0-1) | 37,591 | ||
| at Toronto 6, Minnesota 3 | Halladay (1-0) | Santana (0-1) | Ryan (1) | 50,449 | |
| at Milwaukee 7, Pittsburgh 5 | Capuano (1-0) | Santos (0-1) | Turnbow (2) | 15,515 | |
| at Texas 10, Boston 4 | Padilla (1-0) | Wakefield (0-1) | 29,413 | ||
| Florida 11, at Houston 2 | Mitre (1-0) | Pettitte (0-1) | 36,448 | ||
| at Oakland 4, NY Yankees 3 | Street (1-0) | Proctor (0-1) | 31,284 | ||
| at Seattle 10, LA Angels 8 | Pineiro (1-0) | Lackey (0-1) | 20,051 | ||
| San Francisco at San Diego | Postponed | N/A | |||
| at LA Dodgers 5, Atlanta 4 | Penny (1-0) | Smoltz (0-1) | Baez (1) | 36,249 | |
| Thursday, April 6, 2006 | |||||
| RESULT | WIN | LOSS | SAVE | ATT. | |
| St. Louis 4, at Philadelphia 2 | Marquis (1-0) | Lidle (0-1) | Isringhausen (2) | 20,413 | |
| at San Francisco 6, Atlanta 4 | Fassero (1-0) | Sosa (0-1) | Worrell (2) | 42,795 | |
| Tampa Bay 2, at Baltimore 0 | Hendrickson (1-0) | Benson (0-1) | 13,194 | ||
| at Toronto 6, Minnesota 3 | Chacin (1-0) | Silva (0-1) | Ryan (2) | 16,221 | |
| at Cincinnati 6, Pittsburgh 5 | White (1-0) | Gonzalez (0-1) | Weathers (2) | 13,887 | |
| at NY Mets 10, Washington 5 | Martinez (1-0) | Ortiz (0-1) | 25,839 | ||
| Detroit 10, at Texas 6 | Robertson (1-0) | Dickey (0-1) | 21,729 | ||
| Arizona 12, at Colorado 5 | Batista (1-0) | Francis (0-1) | 18,406 | ||
| at Seattle 6, Oakland 2 | Meche (1-0) | Loaiza (0-1) | Putz (1) | 22,707 | |
| Friday, April 7, 2006 | |||||
| RESULT | WIN | LOSS | SAVE | ATT. | |
| at Chicago Cubs 5, St. Louis 1 | Maddux (1-0) | Suppan (0-1) | 40,869 | ||
| at Cleveland 11, Minnesota 6 | Byrd (1-0) | Lohse (0-1) | 42,445 | ||
| Boston 14, at Baltimore 8 | Clement (1-0) | Cabrera (0-1) | 37,063 | ||
| LA Dodgers 5, at Philadelphia 3 | Tomko (1-0) | Floyd (0-1) | Baez (2) | 25,518 | |
| Tampa Bay 9, at Toronto 8 | Dunn (1-0) | Walker (0-1) | Miceli (1) | 15,631 | |
| at Cincinnati 7, Pittsburgh 6 | Milton (1-0) | Maholm (0-1) | Mercker (1) | 16,573 | |
| at NY Mets 9, Florida 3 | Trachsel (1-0) | Vargas (0-1) | 39,761 | ||
| at Milwaukee 3, Arizona 1 | Bush (1-0) | Ortiz (0-1) | Turnbow (4) | 25,737 | |
| Detroit 5, at Texas 2 | Maroth (1-0) | Koronka (0-1) | Rodney (2) | 21,062 | |
| at Houston 6, Washington 1 | Backe (1-0) | Armas (0-1) | 26,978 | ||
| at Kansas City 11, Chicago Sox 7 | Wood (1-0) | Garland (0-1) | 23,289 | ||
| at LA Angels 4, NY Yankees 1 | Escobar (1-0) | Chacon (0-1) | Rodriguez (2) | 44,221 | |
| Oakland 5, at Seattle 0 | Blanton (1-0) | Hernandez (0-1) | 30,612 | ||
| Colorado 10, at San Diego 4 | Fogg (1-0) | Hensley (0-1) | 33,918 | ||
| Atlanta 14, at San Francisco 6 | Remlinger (1-0) | Walker (0-1) | 39,737 | ||
| Saturday, April 8, 2006 | |||||
| RESULT | WIN | LOSS | SAVE | ATT. | |
| at Toronto 8, Tampa Bay 4 | Tallet (1-0) | Childers (0-1) | 18,755 | ||
| Florida at NY Mets | Postponed | N/A | |||
| at Cincinnati 11, Pittsburgh 9 | Harang (1-1) | Perez (0-1) | White (1) | 20,262 | |
| at Milwaukee 5, Arizona 4 | Kolb (1-0) | Vizcaino (0-1) | 29,226 | ||
| at Kansas City 4, Chicago Sox 3 | Dessens (1-0) | Politte (0-1) | Burgos (1) | 18,116 | |
| at Chicago Cubs 3, St. Louis 2 | Howry (1-0) | Thompson (1-1) | Dempster (1) | 40,182 | |
| LA Dodgers at Philadelphia | Postponed | N/A | |||
| at San Francisco 12, Atlanta 6 | Wright (1-0) | Hudson (0-1) | 39,051 | ||
| Boston 2, at Baltimore 1 | Schilling (2-0) | Chen (0-1) | Papelbon (2) | 41,166 | |
| at Cleveland 3, Minnesota 0 | Johnson (1-0) | Baker (0-1) | Wickman (2) | 25,107 | |
| Washington 12, at Houston 8 | Hernandez (1-1) | Qualls (0-1) | 39,324 | ||
| Detroit 7, at Texas 0 | Verlander (1-0) | Millwood (0-2) | 35,115 | ||
| Oakland 3, at Seattle 0 | Zito (1-1) | Moyer (0-1) | Street (1) | 37,904 | |
| at LA Angels 3, NY Yankees 2 | Santana (1-0) | Johnson (1-1) | Rodriguez (3) | 44,044 | |
| Colorado 12, at San Diego 4 | Day (1-0) | Brazelton (0-1) | 29,629 | ||