| Wednesday, April 4, 2012 | |||||
| RESULT | WIN | LOSS | SAVE | ATT. | |
| Detroit 8, at Toledo 3 | |||||
| at NY Yankees 8, NY Mets 3 | |||||
| at Minnesota 8, Fort Myers 7 | |||||
| at Tampa Bay 2, Tampa Bay (F) 1 | |||||
| at Houston 5, Chicago White Sox 5 | |||||
| at Norfolk 6, Baltimore 4 | |||||
| Texas 6, at Frisco 1 | |||||
| LA Angels 8, at LA Dodgers 3 | |||||
| at Arizona 14, Milwaukee 3 | |||||
| Oakland 8, at San Francisco 1 | |||||
| Seattle 7, at Colorado 2 | |||||
| Kansas City 7, at San Diego 6 | |||||
| St. Louis 4, at Miami 1 (Reg. Season) | Lohse (1-0) | Johnson (0-1) | Motte (1) | 36,601 | |
| Thursday, April 5, 2012 | |||||
| RESULT | WIN | LOSS | SAVE | ATT. | |
| at Detroit 3, Boston 2 | Valverde (1-0) | Melancon (0-1) | 45,027 | ||
| at NY Mets 1, Atlanta 0 | Ramirez (1-0) | Hanson (0-1) | Francisco (1) | 42,080 | |
| Philadelphia 1, at Pittsburgh 0 | Halladay (1-0) | Bedard (0-1) | Papelbon (1) | 39,585 | |
| Washington 2, at Chicago Cubs 1 | Clippard (1-0) | Marmol (0-1) | Lidge (1) | 41,176 | |
| Toronto 7, at Cleveland 4 | Perez (1-0) | Asencio (0-1) | 43,190 | ||
| at Cincinnati 4, Miami 0 | Cueto (1-0) | Buehrle (0-1) | 42,956 | ||
| LA Dodgers 5, at San Diego 3 | Lindblom (1-0) | Volquez (0-1) | Guerra (1) | 42,941 | |
| Friday, April 6, 2012 | |||||
| RESULT | WIN | LOSS | SAVE | ATT. | |
| at Texas 3, Chicago White Sox 2 | Lewis (1-0) | Danks (0-1) | Nathan (1) | 49,085 | |
| at Baltimore 4, Minnesota 2 | Arrieta (1-0) | Pavano (0-1) | Johnson (1) | 46,773 | |
| at Tampa Bay 7, NY Yankees 6 | Rodney (1-0) | Rivera (0-1) | 34,078 | ||
| St. Louis 11, at Milwaukee 5 | Garcia (1-0) | Gallardo (0-1) | 46,086 | ||
| at Arizona 5, San Francisco 4 | Kennedy (1-0) | Lincecum (0-1) | Putz (1) | 49,130 | |
| Colorado 5, at Houston 3 | Guthrie (1-0) | Rodriguez (0-1) | Betancourt (1) | 43,464 | |
| at LA Angels 5, Kansas City 0 | Weaver (1-0) | Crow (0-1) | 44,106 | ||
| Seattle 7, at Oakland 3 | Vargas (1-0) | McCarthy (0-1) | 35,067 | ||
| LA Dodgers 6, at San Diego 0 | Billingsley (1-0) | Luebke (0-1) | 32,490 | ||
| Sunday, April 8, 2012 | |||||
| RESULT | WIN | LOSS | SAVE | ATT. | |
| at Cleveland 4, Toronto 3 | Lowe (1-0) | Carreno (0-1) | Perez (1) | 10,518 | |
| at Detroit 13, Boston 12 | Below (2-0) | Melancon (0-2) | 30,788 | ||
| at Cincinnati 6, Miami 5 | Chapman (1-0) | Bell (0-1) | 23,539 | ||
| at NY Mets 7, Atlanta 5 | Niese (1-0) | Minor (0-1) | Francisco (3) | 27,855 | |
| at Baltimore 3, Minnesota 1 | Hammel (1-0) | Swarzak (0-1) | Johnson (2) | 14,738 | |
| at Pittsburgh 5, Philadelphia 4 | Hanrahan (1-0) | Herndon (0-1) | 19,856 | ||
| at Tampa Bay 3, NY Yankees 0 | Hellickson (1-0) | Hughes (0-1) | Rodney (2) | 30,413 | |
| at Houston 3, Colorado 2 | Lopez (1-0) | Brothers (0-1) | Myers (1) | 14,195 | |
| St. Louis 9, at Milwaukee 3 | Lynn (1-0) | Wolf (0-1) | 33,211 | ||
| at Chicago Cubs 4, Washington 3 | Samardzija (1-0) | Zimmermann (0-1) | Marmol (1) | 31,973 | |
| Kansas City 7, at LA Angels 3 | Sanchez (1-0) | Santana (0-1) | Broxton (1) | 32,227 | |
| at San Diego 8, LA Dodgers 4 | Richard (1-0) | Harang (0-1) | 19,021 | ||
| at Arizona 7, San Francisco 6 | Miley (1-0) | Affeldt (0-1) | Shaw (1) | 24,193 | |
| at Texas 5, Chicago White Sox 0 | Harrison (1-0) | Floyd (0-1) | 45,368 | ||
| Monday, April 9, 2012 | |||||
| RESULT | WIN | LOSS | SAVE | ATT. | |
| Miami 6, at Philadelphia 2 | Sanchez (1-0) | Hamels (0-1) | 45,574 | ||
| LA Angels 5, at Minnesota 1 | Wilson (1-0) | Blackburn (0-1) | 39,414 | ||
| San Francisco 7, at Colorado 0 | Zito (1-0) | Chacin (0-1) | 49,282 | ||
| Milwaukee 7, at Chicago Cubs 5 | Marcum (1-0) | Camp (0-1) | Axford (1) | 38,136 | |
| NY Yankees 6, at Baltimore 2 | Nova (1-0) | Matusz (0-1) | 25,478 | ||
| Chicago White Sox 4, at Cleveland 2 | Sale (1-0) | Tomlin (0-1) | Santiago (2) | 9,473 | |
| Boston 4, at Toronto 2 | Atchison (1-0) | Santos (0-1) | Aceves (1) | 48,473 | |
| St. Louis 7, at Cincinnati 1 | Westbrook (1-0) | Bailey (0-1) | 16,909 | ||
| at NY Mets 4, Washington 3 | Rauch (1-0) | Rodriguez (0-1) | 23,970 | ||
| at Texas 11, Seattle 5 | Darvish (1-0) | Noesi (0-1) | 42,003 | ||
| at Houston 8, Atlanta 3 | Happ (1-0) | Beachy (0-1) | 17,095 | ||
| at Oakland 1, Kansas City 0 | Milone (1-0) | Mendoza (0-1) | Balfour (2) | 10,054 | |
| Tuesday, April 10, 2012 | |||||
| RESULT | WIN | LOSS | SAVE | ATT. | |
| at Detroit 5, Tampa Bay 2 | Coke (1-0) | McGee (0-1) | Valverde (1) | 22,574 | |
| at LA Dodgers 2, Pittsburgh 1 | Jansen (1-0) | Grilli (0-1) | Guerra (3) | 56,000 | |
| NY Yankees 5, at Baltimore 4 | Rapada (1-0) | Strop (0-1) | Rivera (1) | 24,659 | |
| Chicago White Sox at Cleveland | Postponed | N/A | |||
| at Toronto 7, Boston 3 | Drabek (1-0) | Bard (0-1) | 26,351 | ||
| St. Louis 3, at Cincinnati 1 | Lohse (2-0) | Leake (0-1) | Motte (2) | 17,110 | |
| Washington 6, at NY Mets 2 | Detwiler (1-0) | Gee (0-1) | 26,927 | ||
| at Texas 1, Seattle 0 | Feliz (1-0) | Beavan (0-1) | Nathan (2) | 25,753 | |
| Milwaukee 7, at Chicago Cubs 4 | Narveson (1-0) | Maholm (0-1) | Rodriguez (1) | 37,265 | |
| Atlanta 6, at Houston 4 | Hanson (1-1) | Weiland (0-1) | Kimbrel (1) | 22,036 | |
| Kansas City 3, at Oakland 0 | Duffy (1-0) | Godfrey (0-1) | Crow (1) | 10,670 | |
| Arizona 4, at San Diego 2 | Breslow (1-0) | Owings (0-1) | Putz (3) | 18,652 | |