| Pitching | |||||||||||||
| RK | PITCHER | DATE | OPP | SCORE | IP | H | R | ER | BB | SO | PIT | DEC | GSC |
| 1 | Matt Cain, SF | 4/13 | PIT | W 5-0 | 9.0 | 1 | 0 | 0 | 0 | 11 | 106 | W | 96 |
| Philip Humber, CHW | 4/21 | @ SEA | W 4-0 | 9.0 | 0 | 0 | 0 | 0 | 9 | 96 | W | 96 | |
| 3 | Justin Verlander, DET | 5/18 | PIT | W 6-0 | 9.0 | 1 | 0 | 0 | 2 | 12 | 109 | W | 95 |
| Jered Weaver, LAA | 5/2 | MIN | W 9-0 | 9.0 | 0 | 0 | 0 | 1 | 9 | 121 | W | 95 | |
| 5 | Dan Haren, LAA | 5/24 | @ SEA | W 3-0 | 9.0 | 4 | 0 | 0 | 0 | 14 | 126 | W | 93 |
| 6 | Kevin Millwood, SEA | 5/18 | @ COL | W 4-0 | 9.0 | 2 | 0 | 0 | 1 | 7 | 113 | W | 89 |
| Carlos Zambrano, MIA | 5/7 | @ HOU | W 4-0 | 9.0 | 3 | 0 | 0 | 1 | 9 | 109 | W | 89 | |
| Zack Greinke, MIL | 5/9 | CIN | L 1-2 | 8.0 | 2 | 0 | 0 | 0 | 11 | 104 | ND | 89 | |
| Brandon Morrow, TOR | 5/3 | @ LAA | W 5-0 | 9.0 | 3 | 0 | 0 | 0 | 8 | 102 | W | 89 | |
| 10 | Brandon Morrow, TOR | 5/19 | NYM | W 2-0 | 9.0 | 3 | 0 | 0 | 1 | 8 | 107 | W | 88 |
| 11 | Adam Wainwright, STL | 5/22 | SD | W 4-0 | 9.0 | 4 | 0 | 0 | 1 | 9 | 111 | W | 87 |
| Edwin Jackson, WSH | 4/14 | CIN | W 4-1 | 9.0 | 2 | 1 | 1 | 1 | 9 | 92 | W | 87 | |
| Joe Blanton, PHI | 5/3 | @ ATL | W 4-0 | 9.0 | 3 | 0 | 0 | 0 | 6 | 88 | W | 87 | |
| Felix Hernandez, SEA | 5/5 | MIN | W 7-0 | 8.0 | 1 | 0 | 0 | 2 | 9 | 107 | W | 87 | |
| Chad Billingsley, LAD | 4/6 | @ SD | W 6-0 | 8.1 | 3 | 0 | 0 | 1 | 11 | 108 | W | 87 | |
| 16 | Johan Santana, NYM | 5/26 | SD | W 9-0 | 9.0 | 4 | 0 | 0 | 0 | 7 | 96 | W | 86 |
| Jerome Williams, LAA | 5/1 | MIN | W 4-0 | 9.0 | 3 | 0 | 0 | 1 | 6 | 109 | W | 86 | |
| Matt Cain, SF | 4/18 | PHI | W 1-0 | 9.0 | 2 | 0 | 0 | 1 | 4 | 91 | ND | 86 | |
| 19 | Cliff Lee, PHI | 4/18 | @ SF | L 0-1 | 10.0 | 7 | 0 | 0 | 0 | 7 | 102 | ND | 85 |
| C.J. Wilson, LAA | 5/22 | @ OAK | W 5-0 | 8.0 | 1 | 0 | 0 | 2 | 7 | 125 | W | 85 | |
| Matt Garza, CHC | 4/12 | MIL | W 8-0 | 8.2 | 3 | 0 | 0 | 2 | 9 | 119 | W | 85 | |
| 22 | Jake Peavy, CHW | 4/23 | @ OAK | W 4-0 | 9.0 | 3 | 0 | 0 | 2 | 5 | 107 | W | 84 |
| Justin Verlander, DET | 4/5 | BOS | W 3-2 | 8.0 | 2 | 0 | 0 | 1 | 7 | 105 | ND | 84 | |
| Jered Weaver, LAA | 4/6 | KC | W 5-0 | 8.0 | 4 | 0 | 0 | 0 | 10 | 97 | W | 84 | |
| Matt Garza, CHC | 4/29 | @ PHI | W 5-1 | 7.0 | 1 | 0 | 0 | 1 | 10 | 103 | W | 84 | |
| 26 | Roy Halladay, PHI | 4/5 | @ PIT | W 1-0 | 8.0 | 2 | 0 | 0 | 0 | 5 | 92 | W | 83 |
| Barry Zito, SF | 4/9 | @ COL | W 7-0 | 9.0 | 4 | 0 | 0 | 0 | 4 | 114 | W | 83 | |
| Felix Hernandez, SEA | 4/19 | CLE | L 1-2 | 8.0 | 5 | 0 | 0 | 1 | 12 | 126 | ND | 83 | |
| Joe Saunders, ARI | 4/27 | @ MIA | W 5-0 | 9.0 | 3 | 0 | 0 | 2 | 4 | 116 | W | 83 | |
| David Price, TB | 5/4 | OAK | W 7-2 | 8.0 | 3 | 1 | 1 | 1 | 12 | 106 | W | 83 | |
| Justin Masterson, CLE | 4/5 | TOR | L 4-7 | 8.0 | 2 | 1 | 1 | 1 | 10 | 99 | ND | 83 | |
| Brandon Beachy, ATL | 5/17 | MIA | W 7-0 | 9.0 | 5 | 0 | 0 | 0 | 6 | 122 | W | 83 | |
| 33 | Andy Pettitte, NYY | 5/18 | CIN | W 4-0 | 8.0 | 4 | 0 | 0 | 1 | 9 | 115 | W | 82 |
| David Price, TB | 4/24 | LAA | W 5-0 | 9.0 | 5 | 0 | 0 | 1 | 6 | 119 | W | 82 | |
| 35 | Ryan Dempster, CHC | 5/3 | @ CIN | L 3-4 | 8.0 | 3 | 0 | 0 | 1 | 6 | 101 | ND | 81 |
| Jake Peavy, CHW | 4/28 | BOS | L 0-1 | 9.0 | 4 | 1 | 1 | 1 | 7 | 116 | L | 81 | |
| Jake Arrieta, BAL | 5/2 | @ NYY | W 5-0 | 8.0 | 5 | 0 | 0 | 0 | 9 | 111 | W | 81 | |
| Cory Luebke, SD | 4/21 | PHI | W 5-1 | 8.0 | 2 | 0 | 0 | 2 | 5 | 110 | W | 81 | |
| Tommy Milone, OAK | 4/24 | CHW | W 2-0 | 8.0 | 3 | 0 | 0 | 0 | 5 | 98 | W | 81 | |
| 40 | Gio Gonzalez, WSH | 4/12 | CIN | W 3-2 | 7.0 | 2 | 0 | 0 | 0 | 7 | 97 | ND | 80 |