| Pitching | |||||||||||||
| RK | PITCHER | DATE | OPP | SCORE | IP | H | R | ER | BB | SO | PIT | DEC | GSC |
| 1 | Yu Darvish, TEX | 4/2 | @ HOU | W 7-0 | 8.2 | 1 | 0 | 0 | 0 | 14 | 111 | W | 96 |
| 2 | Chris Sale, CHW | 5/12 | LAA | W 3-0 | 9.0 | 1 | 0 | 0 | 0 | 7 | 98 | W | 92 |
| 3 | Jon Lester, BOS | 5/10 | TOR | W 5-0 | 9.0 | 1 | 0 | 0 | 0 | 5 | 118 | W | 90 |
| 4 | Anibal Sanchez, DET | 4/26 | ATL | W 10-0 | 8.0 | 5 | 0 | 0 | 1 | 17 | 121 | W | 88 |
| 5 | James Shields, KC | 5/6 | CHW | L 1-2 | 8.0 | 2 | 0 | 0 | 2 | 9 | 102 | ND | 85 |
| Clay Buchholz, BOS | 4/14 | TB | W 5-0 | 8.0 | 2 | 0 | 0 | 4 | 11 | 109 | W | 85 | |
| Justin Masterson, CLE | 5/13 | NYY | W 1-0 | 9.0 | 4 | 0 | 0 | 3 | 9 | 118 | W | 85 | |
| 8 | Justin Masterson, CLE | 4/12 | CHW | W 1-0 | 9.0 | 5 | 0 | 0 | 1 | 7 | 113 | W | 83 |
| Alex Cobb, TB | 4/24 | NYY | W 3-0 | 8.1 | 3 | 0 | 0 | 1 | 7 | 106 | W | 83 | |
| 10 | Jason Vargas, LAA | 5/3 | BAL | W 4-0 | 9.0 | 3 | 0 | 0 | 2 | 3 | 107 | W | 82 |
| Hiroki Kuroda, NYY | 4/14 | BAL | W 3-0 | 9.0 | 5 | 0 | 0 | 0 | 5 | 113 | W | 82 | |
| Hiroki Kuroda, NYY | 5/17 | TOR | W 5-0 | 8.0 | 2 | 0 | 0 | 1 | 5 | 109 | W | 82 | |
| Chris Sale, CHW | 5/17 | @ LAA | W 3-0 | 7.2 | 3 | 0 | 0 | 3 | 12 | 113 | W | 82 | |
| Jose Quintana, CHW | 4/12 | @ CLE | L 0-1 | 7.0 | 1 | 0 | 0 | 0 | 7 | 98 | ND | 82 | |
| 15 | Jeremy Guthrie, KC | 5/4 | CHW | W 2-0 | 9.0 | 4 | 0 | 0 | 1 | 3 | 106 | W | 81 |
| Phil Hughes, NYY | 5/4 | OAK | W 4-2 | 8.0 | 4 | 0 | 0 | 2 | 9 | 118 | W | 81 | |
| Garrett Richards, LAA | 4/20 | DET | W 10-0 | 7.0 | 2 | 0 | 0 | 0 | 8 | 99 | W | 81 | |
| Wei-Yin Chen, BAL | 4/26 | @ OAK | W 3-0 | 8.0 | 2 | 0 | 0 | 2 | 5 | 106 | W | 81 | |
| 19 | Felix Hernandez, SEA | 4/17 | DET | L 1-2 | 8.0 | 5 | 1 | 1 | 0 | 12 | 106 | ND | 80 |
| Felix Hernandez, SEA | 4/1 | @ OAK | W 2-0 | 7.2 | 3 | 0 | 0 | 1 | 8 | 109 | W | 80 | |
| Justin Verlander, DET | 5/5 | @ HOU | W 9-0 | 7.0 | 2 | 0 | 0 | 2 | 9 | 116 | W | 80 | |
| Max Scherzer, DET | 5/21 | @ CLE | W 5-1 | 8.0 | 2 | 1 | 1 | 1 | 7 | 118 | W | 80 | |
| Justin Masterson, CLE | 5/19 | SEA | W 6-0 | 7.0 | 3 | 0 | 0 | 2 | 11 | 106 | W | 80 | |
| Matt Moore, TB | 4/22 | NYY | W 5-1 | 8.0 | 2 | 1 | 1 | 3 | 9 | 117 | W | 80 | |
| 25 | Felix Hernandez, SEA | 5/3 | @ TOR | W 4-0 | 8.0 | 5 | 0 | 0 | 0 | 7 | 95 | W | 79 |
| Derek Holland, TEX | 4/16 | @ CHC | W 4-2 | 7.0 | 2 | 0 | 0 | 0 | 6 | 108 | W | 79 | |
| 27 | Clay Buchholz, BOS | 5/1 | @ TOR | W 10-1 | 7.0 | 2 | 0 | 0 | 3 | 8 | 101 | W | 78 |
| Max Scherzer, DET | 5/4 | @ HOU | W 17-2 | 8.0 | 3 | 1 | 1 | 2 | 8 | 105 | W | 78 | |
| Justin Masterson, CLE | 4/7 | @ TB | W 13-0 | 7.0 | 2 | 0 | 0 | 3 | 8 | 97 | W | 78 | |
| Derek Holland, TEX | 5/3 | BOS | W 7-0 | 8.0 | 6 | 0 | 0 | 1 | 9 | 112 | W | 78 | |
| Yu Darvish, TEX | 4/19 | SEA | W 7-0 | 7.0 | 3 | 0 | 0 | 3 | 10 | 111 | W | 78 | |
| Dan Straily, OAK | 5/21 | @ TEX | W 1-0 | 7.0 | 2 | 0 | 0 | 0 | 5 | 88 | W | 78 | |
| 33 | Bartolo Colon, OAK | 4/23 | @ BOS | W 13-0 | 7.0 | 3 | 0 | 0 | 1 | 7 | 94 | W | 77 |
| Ryan Dempster, BOS | 4/15 | TB | W 3-2 | 7.0 | 2 | 1 | 1 | 2 | 10 | 101 | ND | 77 | |
| Max Scherzer, DET | 4/17 | @ SEA | W 2-1 | 8.0 | 6 | 1 | 1 | 1 | 12 | 105 | ND | 77 | |
| Chris Tillman, BAL | 5/2 | @ LAA | W 5-1 | 8.0 | 3 | 0 | 0 | 2 | 3 | 114 | W | 77 | |
| 37 | Jeremy Hellickson, TB | 4/20 | OAK | W 1-0 | 7.0 | 3 | 0 | 0 | 1 | 6 | 100 | W | 76 |
| 38 | Clay Buchholz, BOS | 4/8 | BAL | W 3-1 | 7.0 | 3 | 0 | 0 | 4 | 8 | 113 | W | 75 |
| Hector Santiago, CHW | 5/7 | @ NYM | L 0-1 | 7.0 | 4 | 0 | 0 | 2 | 8 | 111 | ND | 75 | |
| Yu Darvish, TEX | 4/24 | @ LAA | W 11-3 | 6.0 | 3 | 0 | 0 | 2 | 11 | 100 | W | 75 | |