The game will be nationally televised on MLB Network. It will highlight a series of activities, including the MLB Beacon Awards luncheon, a baseball and civil rights movement roundtable discussion and youth baseball and softball games.
Commissioner Bud Selig announced the game and says the Astros have "demonstrated a substantial commitment to supporting diversity throughout our industry."
It will be the eighth annual installment of the game, which pays tribute to those who fought for equal rights on and off the field. It began in Memphis in 2007 as an exhibition game and was hosted last season by the White Sox.