Manager Buck Showalter said he would have an MRI on Saturday.
Pearce did not return for the fourth inning after he went to his right to snare a grounder before throwing to pitcher Miguel Gonzalez.
"I'm just hoping it's a day or two thing,'' Pearce said. "I'm not feeling any pain or anything, just discomfort.''
If Pearce is sidelined for a spell, Chris Davis will do his best to make sure there's no reduction in the team's offensive output. He has 14 hits in August, seven of them home runs, and has accounted for 24 of Baltimore's major-league leading 172 home runs.
Pearce came into the season as a utility player but eventually earned a starting role with the AL East leaders. He came into the game with a .290 batting average, 16 homers and 37 RBIs.
His career-high 11-game hitting streak ended Friday, as he grounded out in his only at-bat before leaving the game.
Earlier in the game, Pearce drifted near the stands in pursuit of a foul pop by Trevor Plouffe. He leaned into the front row, leaped to make the catch and ended up taking a seat on the concrete border.
The Associated Press contributed to this report.