"It depends on the circumstances of each case," Manfred said Monday during the Rockies' exhibition game against the Chicago Cubs. "I can imagine a scenario where you're able to get all the information and put yourself in a position to make a decision.
"On the other hand, I think the single biggest mistake you can make here is to make a decision quickly and then have additional facts come out afterward and undermine the quality of that decision."
Before spring training, Manfred placed Reyes on paid suspension under the domestic violence agreement reached in August. Last week, Yankees closer Aroldis Chapman agreed to a 30-game suspension.
Reyes is scheduled for an April 4 trial on a charge that he abused his wife Oct. 31 at a Hawaii resort. Reyes has pleaded not guilty.
"Once that process plays out, I think we'll be in a position to have access to all the facts and be in a position to act quickly," Manfred said.
Manfred said each domestic violence case is different.
"And they're not just what you think the facts are -- it's also what facts you can prove," Manfred said. "We're just not in a position to have a great grasp of the facts quite yet. I think we'll be in a much better position once the legal process plays out."
Among other matters, Manfred indicated that he is preparing for frequent meetings with the union on a new labor contract.
"We've had one meeting already, and they will continue during spring training," he said. "I don't talk about the substance of those, other than to say we got a nice, early start, and that's a good thing for everybody."
Manfred said his office consulted with the union before submitting a proposal to the U.S. Treasury Department that would allow teams to sign Cuban players without players having to establish residence outside the island nation.
"We did have a conversation about it. It's pending," Manfred said. "It's really in the government's hands at this point, and I don't necessarily expect quick action there."