Griffin left with two outs in the second inning.
Although nothing appeared out of the ordinary, the A's trainer bolted from the dugout after Yan Gomes flied out. Griffin was immediately pulled from the game and replaced by Jordan Norberto, who gave up four hits over a career-high 3 2/3 innings.
Griffin (3-0, 2.42 ERA) gave up a leadoff single to Yunel Escobar and then retired five straight.
The A's lost 3-1 in 11 innings.
Information from The Associated Press was used in this report.