Gutierrez, who has been on the disabled list since June 25 and with a strained right hamstring, was expected to start Monday's game against the Texas Rangers in right field.
"It feels good to be back again," he said. "It's been a long time. I'm really happy I'm coming back to help my team."
Gutierrez was also on the disabled list from May 16-June 2 because of the same ailment, and he has had four rehab assignments with Tacoma this season. In 18 games for the Mariners, Gutierrez is batting .267 with five home runs and 11 RBI.
"I'm happy to see him back, and we're throwing him right in there," Seattle manager Eric Wedge said.
In addition to the hamstring issues, Gutierrez was diagnosed with a type of arthritis that causes inflammation in the back.
"Right now, I feel like it's under control," Gutierrez said. "I've got three months with the medicine. The healing process has been slow, but good. I'm feeling much better. I don't have as much pain."
Seattle designated right-hander Aaron Harang for assignment. Harang (5-11, 5.76 ERA) started 22 games for the Mariners. He lost 7-1 to the Angels on Sunday, giving up all the runs.
"This is the actual first time I've been told face-to-face I've been designated," Harang said. "It's a little tougher than expected, but I get it. I had some inconsistencies that I've got to work on. I know I can still pitch and be successful at this level."