The UFC's annual Memorial Day weekend event will take place at the MGM Grand Garden Arena. Las Vegas Review Journal first reported the heavyweight bout.
Dos Santos (16-3) won the UFC title in November 2011 in a first-round knockout over Cain Velasquez. Following one title defense against Frank Mir, dos Santos lost the belt back to Velasquez via unanimous decision in December 2012.
In October, dos Santos attempted to recapture the belt against Velasquez at UFC 166. He lost via TKO in the fifth round.
Last month, UFC president Dana White attempted to book a fight between dos Santos and Alistair Overeem. Overeem (37-13) declined, citing a rib injury.