The event, which will stream on the UFC's Fight Pass Internet service, will take place at 02 World Berlin in Germany. UFC officials announced the main event Thursday.
Mousasi (34-4-2) seeks his first win in the UFC middleweight division. He suffered a unanimous decision loss to No. 1 contender Lyoto Machida in his previous performance, at a UFC Fight Night event last month.
A former 205-pound champion in Strikeforce and Dream, Mousasi dropped to 185 pounds following a successful UFC debut at light heavyweight against Ilir Latifi. The 28-year-old saw a four-fight win streak snapped in the loss to Machida.
Munoz (13-4) is also coming off a loss to Machida in his last bout. The California-based middleweight hasn't fought since October, when he suffered a first-round head kick knockout to Machida in England.
The Berlin event will be the UFC's first in the German capital. A second international event is expected to take place in Brazil on the same day.