Struve (25-6) hasn't fought since March 2013 and was nearly forced into retirement due to a bicuspid aortic valve -- a rare heart disorder that disrupts blood flow.
The 26-year-old responded well to treatment late last year and eventually was cleared by physicians in his native Holland. He currently is visiting Los Angeles, where doctors recently cleared him to compete again.
Struve suffered a TKO loss to Mark Hunt in the third round of his last fight. Prior to the loss, he had finished four consecutive opponents.
Mitrione (7-3) is coming off a first-round knockout over Shawn Jordan in March. A former contestant on "The Ultimate Fighter," Mitrione has recorded knockouts in six of his seven pro wins.