Hominick (20-11) has not tasted success since a unanimous-decision loss to 145-pound champion Jose Aldo on April 30, 2011.
In his next fight that December, Hominick was knocked out in seven seconds by Chan Sung Jung. He then came out on the short end of a split decision against Eddie Yagin on April 21.
The recent setbacks have not diminished Hominick's confidence.
"So pumped to be on (the) Montreal card against Pablo Garza," Hominick said on Twitter.
Hominick is a solid striker with impressive takedown defense. He must be at his best in that area to stay off the ground against Garza (11-3), who possesses above-average submission skills.
Seven of Garza's wins have come via submission. He has, however, lost his past two fights.
Middleweight Francis Carmont, who has yet to lose a fight in UFC, meets Tom Lawlor on the Nov. 17 card.
Carmont is 19-7 and is sporting an eight-fight win streak. He is 3-0 inside the Octagon.
Lawlor (8-4, one no contest) knocked out Jason MacDonald in 50 seconds on May 15.