The bout is expected to be on TUF Season 16 finale's main card, which will be held at the Hard Rock Hotel and Casino.
Poirier (12-2) looks to rebound from a fourth-round submission loss to Chan Sung Jung in May. That loss snapped a five-fight win streak for Poirier, who is ranked seventh by ESPN.com among 145-pound fighters.
Brookins also is looking to bounce back from a submission loss. He was the victim of an anaconda choke June 1 against Charles Oliveira.
Life inside the Octagon has been difficult for Brookins (13-5) since winning TUF in December 2010 with a unanimous decision over Michael Johnson.
Brookins has lost two of his three most recent bouts.