The heavyweights meet again in an improbable rematch Saturday at the MGM Grand Garden Arena in Las Vegas for UFC 160, this time with a title on the line.
Velasquez, a two-time UFC champion, recaptured the belt in December after a five-round decision over Junior dos Santos.
The 30-year-old Mexican-American champion weighed 240 pounds. His 6-foot-4 challenger stepped on the scale at 263, 2 pounds under the division limit.
"Bigfoot is dangerous," Velasquez said. "I'm not taking him lightly going into the fight, for sure. This right now means everything for me. Staying here. Staying in this position. Holding the belt. Keeping the belt here."
"I'm very excited to fight tomorrow," Silva said. "I'm ready for this fight. I trained a lot. And I want to win this belt, for sure."
Zuffa's traditional Memorial Day weekend offering in Las Vegas features a heavyweight tilt pitting dos Santos (15-2) against Mark Hunt (9-7) in the co-main event.
The winner could be next in line to fight for the UFC title.
Dos Santos, 28, weighed 239 pounds. Hunt (9-7), bothered by visa issues and subsequently delayed getting into the U.S. from Australia, appeared to be a robust 264 pounds.
Hunt, 39, has reeled off four consecutive victories. The former K-1 kickboxing champion's transition to MMA would reach new heights if he's able to get pass "Cigano."
Grant, who weighed 155 pounds, is unbeaten in four fights at lightweight.
Maynard, 34, returns to the Octagon after winning an ugly decision against Clay Guida. He checked in at 156 pounds.