Wade, who has been dealing with soreness in his right knee, confirmed he would play during a pregame session with reporters in the Heat's locker room about 90 minutes before the start of the Eastern Conference semifinal game.
"There's really no story here, there's nothing new," Wade said. "It's the same thing I've been dealing with. It's not getting better [and] it's not getting worse. So I'm going to go out there and try to help my team win."
Wade has been receiving extensive treatment for multiple bone bruises in his right knee for the past two months. He aggravated the injury in Monday's victory against the Bulls in Chicago when he bumped knees with Jimmy Butler in the second quarter and temporarily left the game to receive treatment.
Heat coach Erik Spoelstra had said Wade's status wouldn't be determined until just before the game, which opened the possibility he might consider sitting the All-Star guard. Wade missed Game 4 of the Heat's first-round sweep of the Milwaukee Bucks.
The soreness has left Wade struggling to find his offensive rhythm throughout the playoffs. He's averaging just 12.3 points in the postseason.
The Heat have a 3-1 series lead and are looking to advance to the Eastern Conference finals for the third consecutive season.