MIAMI (AP) -- Bobby Jackson kept looking over his left shoulder as he strode toward the basket for what could have been an easy lay-up.
He never saw Dwyane Wade coming from the right.
Wade scored 18 of his 25 points in the second half, and he helped frustrate former Heat guard Eddie Jones into an 0-for-7 performance in his first game in Miami since he was traded in the five-team, 13-player megadeal last summer that brought Jason Williams and James Posey to the Heat.
"Coach did put a challenge out there for me to be more active on defense, to be more aware," said Wade, who added four rebounds, four assists, three blocks and two steals. "I know I'm a good defender. At times, I just take a rest. So he put a challenge on me not to take a rest."
It wasn't just Wade responding to Pat Riley's call for better defense. The Heat outrebounded Memphis 47-30, plus held the Grizzlies to 52 points and 34 percent shooting over the final three periods.
Shaquille O'Neal had 20 points and 15 rebounds in 30 minutes for Miami, which won its 51st consecutive home game when leading after three quarters. Williams added 14 points and six assists for the Heat, who have won two straight.
"If we do what we're supposed to do, we can play with any team," said O'Neal, repeating a familiar refrain. "We just have to play good defense, contain their shooters, not let them have three or four guys in double figures. If we do that, we'll be fine."
"Obviously, the third quarter was when the game turned around," Memphis coach Mike Fratello said. "And it started with us picking up fouls and putting us in the bonus early."
Wade had 13 points in the third quarter alone, falling one point short of matching Memphis' total in the period. The Grizzlies went without a field goal for the first 4:55 of the third, shot 3-for-15 in the period and saw a one-point halftime deficit become a 75-61 margin entering the fourth.
Wade had eight points in Miami's 19-8 run to open the third quarter, including a pair of free throws with 3:46 left that pushed the Heat lead to 67-55. Memphis never got closer than nine points the rest of the way.
"I was on the bench watching and I wanted to be out there competing against him," said Jones, who missed much of the third quarter after picking up his fourth foul. "He's a heck of a player. When you run into great players you want to be out there competing with them."
Jones finished with two points after shooting 0-for-7 from the floor and 2-for-7 from the foul line.
"You have nights like that when you want it so bad," Jones said.
The Heat outrebounded Memphis 47-30, plus got to the foul line 46 times compared with 27 by the Grizzlies. Udonis Haslem had 11 rebounds for the Heat.
Memphis stayed close in large part with 3-point shooting; the Grizzlies were 10-for-28 from behind the arc, with Jackson shooting 5-for-9 from long range.
"They were attacking the basket and the officials were calling everything for them," Jackson said. "What else can you do? ... We knew they would come out and push the ball. We weren't ready for it."
The game was the 1,700th of Riley's coaching career, and the 700th home game for the Heat franchise. ... Memphis, which entered the game with the NBA's third-lowest team free-throw percentage, connected on 13 of 24 tries through three quarters. ...
Miami is 8-2 when O'Neal has a double-double. ... Memphis fell to 16-4 in games where it leads after the first quarter. ... Gasol is averaging 11.3 points in his last four games. He was averaging 19.9 points before that.