Andre Miller scored 22 points, and the 76ers spoiled D'Antoni's first preseason home game at Madison Square Garden with a 116-109 victory over the Knicks on Tuesday night.
"It's tough because it's early and we're still trying to get in shape, and it's a long season," Miller said. "But it's good to play against a D'Antoni offense where the guys want to get up and down the court. It definitely helped us tonight."
D'Antoni was hired in May, bringing his high-scoring brand of basketball that turned the Phoenix Suns into one of the NBA's top teams over the last four seasons. And while the Knicks appear much better offensively, they struggled to get stops, essentially trading baskets for most of the second half.
Though the Knicks have basically the same personnel that went 23-59 last season, D'Antoni remains confident his system can work in New York.
"I've very excited about them," he said. "Obviously there's some stuff we've got to do better. We've got to get a lot better defensively. (But) We have enough. We have enough."
The 76ers like to push the pace, turning to a more uptempo offense last season to make a strong finishing push and earn a playoff berth. They looked comfortable Tuesday, shooting 51 percent from the floor and getting 56 points in the paint.
Coach Maurice Cheeks left four starters on the floor for more than 30 minutes, using the fast pace of the game to get his key players in better condition.
"This was a good game to get in game shape, the way they run, the way they push the ball up," Cheeks said. "Practice is one thing, but being able to get in game shape is another and this was certainly a good game to do that."
Andre Iguodala added 18 points and Thaddeus Young had 16 for the 76ers (3-1) in the second meeting between the Atlantic Division rivals in five nights. The Knicks won 110-104 last Friday night in Philadelphia.
Elton Brand, Philadelphia's key offseason addition, was only 3-of-12 but finished with 13 points and 11 rebounds.
Zach Randolph and David Lee each finished with 17 points for New York (1-2), but Lee was only 5-of-11 after making 17 of 23 shots (74 percent) in the first two games.
"I was energized for about 30 minutes," Lee said, "but those last four or five I was really feeling it."
Mardy Collins added 10 points, making all five shots in 11 minutes.
D'Antoni has been keeping to a tighter rotation than many coaches do in the preseason while trying to figure out exactly what he inherited from Isiah Thomas. He didn't use three healthy players and two others played less than 10 minutes. Stephon Marbury, now a reserve, was scoreless in 21 minutes.
Eddy Curry made his preseason debut late in first quarter. He missed the entire first week of practice with a bacterial infection, and D'Antoni felt he wasn't ready to play in either of the first two games.
Curry played 6 minutes in the first half, missing both shots from the field and scoring one point, then didn't return for the second because of an upset stomach.
Miller was 6-of-7 in the first quarter for 12 points, leading Philadelphia to a 32-24 lead. The Knicks cut it to 59-57 at halftime and grabbed the lead early in the third before the Sixers went back ahead 89-85 heading to the fourth.