Kobe Bryant finished with 22 points and six rebounds in 28 minutes for the Lakers (0-5), while Pau Gasol had 20 points and six rebounds in 31 minutes for the Kings (3-1), who only trailed once.
Steve Nash added eight points and six assists in 28 minutes for the Lakers. All three did not play in the fourth quarter.
The Lakers' Dwight Howard will try to play Sunday night against Sacramento in Los Angeles. It will be determined by the Lakers medical staff. Howard, who had back surgery last April, made the trip to Las Vegas.