Williams scored 13 points and Pekovic added 10 during an opening burst that gave the Timberwolves a 27-10 lead in the first quarter. Minnesota pushed its lead to 52-29 at the half.
The Pistons showed some life after the break, going on an 8-0 run to close the gap to five. Stuckey scored 13 third-quarter points after putting in eight in the opening half.
The Timberwolves bounced back to stretch their lead to 68-53 entering the fourth and were in control throughout the final quarter.