Indiana (29-7) used an 11-3 run in the third quarter to create separation from Washington. Two field goals from West capped the swing, which put the Pacers up 56-40.
The Wizards (16-18) stumbled at the foul line. They finished 9 of 23 on free throws, hitting just five of their first 14.
West helped pick up the Pacers, connecting on his first five field goals.
The Bucks saved money on Wednesday by releasing forwards Damien Inglis and Johnny O'Bryant.
Dave McMenamin explains why the Cavaliers aren't worried about LeBron James and coach Tyronn Lue signing new contracts to stay in Cleveland.
What is No. 1 free agent LeBron James really worth? Kevin Pelton projects the future for the top NBA superstars to get their true value -- and explains why the forecast could come true.