Splitter had a season-high 22 points before he was hurt, Tim Duncan added 19 points and 11 rebounds, and San Antonio beat Los Angeles 116-92 Saturday night in their first game without injured All-Star Chris Paul.
Splitter left with 9:37 remaining, injuring his right shoulder after charging into Ryan Hollins' chest.
Jamal Crawford scored 24 points, Blake Griffin had 19 points and Darren Collison added 14 points and six assists starting in place of Paul, who separated his right shoulder Friday night against the Dallas Mavericks.
Los Angeles gave up 70 points in the first half for the second consecutive night, but rallying proved tougher to do against a 35-point lead than the three-point deficit they faced against Dallas.
"It's easier to do it once you play so bad the game before because you know the mistakes you made," Ginobili said. "We were really sharp from the beginning; our first half was great. Then we kind of stopped a little bit, but the first half was fun to watch. Everybody sharing the ball, attacking, being quick, rotations real sharp, really good first half."
While the Clippers understandably stalled without their leader, who is expected to be out three to five weeks, the rest of their game disappeared, too.
"No one has to replace Chris' anything," Griffin said. "Not his voice, not his game, nothing. Everybody does things differently. We don't have any other guys that talk like Chris. It'll work just fine. In the second half we were communicating with each other. That's all we needed. We didn't need anyone to talk like Chris. That would be our biggest mistake, is to try to replace him with someone or something."
Los Angeles had just one rebound in the first quarter while allowing San Antonio to score a season-high 37 points.
"In the first half we looked more AAU," Clippers coach Doc Rivers said. "The ball stuck. I bet half the time it was one pass, shot; one pass, shot."
After Collison's jumper with 2:20 left in the first, Los Angeles didn't score again until Matt Barnes' layup with 9:40 left in the half. San Antonio extended its lead to 70-35 at the half, its season high for point in an opening half.
Spurs F Boris Diaw missed the game with an undisclosed illness. ... The Clippers' Stephen Jackson received a mixed reaction upon entering the game in the final 2 minutes. Jackson was waived late last season after reportedly butting heads with Spurs coach Gregg Popovich. ... The Spurs' public address announcer mistakenly screamed "Manu Ginobili" in the opening minute of game, crediting him with an assist on Splitter's basket even though the guard had yet to enter. The assist actually belonged to Marco Belinelli, Ginobili's friend and former Euroleague teammate. ... When the shot clock reset incorrectly late in the third quarter, Rivers asked if they could start over. After official Monty McCutchen said they would reset it, Rivers said, "No, can we start the game over?"