Indiana (29-7) used an 11-3 run in the third quarter to create separation from Washington. Two field goals from West capped the swing, which put the Pacers up 56-40.
The Wizards (16-18) stumbled at the foul line. They finished 9 of 23 on free throws, hitting just five of their first 14.
West helped pick up the Pacers, connecting on his first five field goals.